INT152554

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.52
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
Anatomy Link Frequency
gut 4
lymphoblast 2
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 16 94.32 High High
sSRI 9 89.04 High High
Nicotine 34 84.48 Quite High
Serotonin 16 77.80 Quite High
addiction 7 53.20 Quite High
tolerance 10 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

12 94.32 High High
Stress 2 92.12 High High
Functional Bowel Disorder 4 82.16 Quite High
Congenital Anomalies 2 74.52 Quite High
Nicotine Addiction 65 55.44 Quite High
Depression 7 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Substance Withdrawal Syndrome 1 5.00 Very Low Very Low Very Low
Premenstrual Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent molecular studies have raised critical questions about multiple SERT mRNA transcripts in the human gut, the role of polymorphic SERT promoter in the regulation of enteric SERT expression and the ability of 5-HTTLPR to affect human SERT gene transcription.
Regulation (role) of Transcription (transcription) of SERT in gut
1) Confidence 0.62 Published 2008 Journal Trends Mol Med Section Abstract Doc Link 18550438 Disease Relevance 0.23 Pain Relevance 1.01
Recent studies have shown that 5-HTTLPR polymorphisms have significant effects on 5-HTT mRNA expression in lymphoblast cell lines and that the average methylation was higher among short alleles with trends for linearity with heterozygotes as an intermediate (41,42).
Regulation (effects) of Transcription (expression) of 5-HTT in lymphoblast
2) Confidence 0.54 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852756 Disease Relevance 0.20 Pain Relevance 0.20
Recent molecular studies have raised critical questions about multiple SERT mRNA transcripts in the human gut, the role of polymorphic SERT promoter in the regulation of enteric SERT expression and the ability of 5-HTTLPR to affect human SERT gene transcription.
Regulation (affect) of Transcription (transcription) of SERT in gut
3) Confidence 0.27 Published 2008 Journal Trends Mol Med Section Abstract Doc Link 18550438 Disease Relevance 0.22 Pain Relevance 0.97

General Comments

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