INT152564

Context Info Confidence 0.52 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.34 Pain Relevance 0.70

mitochondrion (DECR1) small molecule metabolic process (DECR1) nucleolus (DECR1) nucleus (DECR1) cytoplasm (DECR1)

Anatomy Link Frequency endothelial cells 1 DECR1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 12 98.74 COX2 4 88.08 diclofenac 2 84.56

Disease Link Frequency Relevance Heat Hypertension 1 98.44 INFLAMMATION 2 91.20 Stress 2 75.00 Increased Venous Pressure Under Development 1 25.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

The current study was designed to test the effect of coxibs and nonselective NSAIDs on vascular superoxide and nitric oxide (NO) production. mRNA expression of endothelial NO synthase (eNOS) and of the vascular NADPH oxidases was studied in spontaneously hypertensive rats (SHR) and in human endothelial cells.

Transcription (expression) of NADPH in endothelial cells associated with hypertension and cinod

1) Confidence 0.52 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.34 Pain Relevance 0.70

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