INT15257

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Context Info
Confidence 0.21
First Reported 1991
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.75
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nkx2-2) nucleus (Nkx2-2) molecular_function (Nkx2-2)
transcription factor binding (Nkx2-2)
Anatomy Link Frequency
spinal 3
urinary bladder 1
NK-3 1
synapses 1
NK-2 1
Nkx2-2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 42 99.56 Very High Very High Very High
long-term potentiation 97 99.34 Very High Very High Very High
substance P 28 99.34 Very High Very High Very High
analgesia 1 99.16 Very High Very High Very High
qutenza 4 98.88 Very High Very High Very High
Glutamate receptor 2 98.48 Very High Very High Very High
Spinal cord 23 97.80 Very High Very High Very High
antagonist 21 97.44 Very High Very High Very High
agonist 16 97.12 Very High Very High Very High
Calcium channel 1 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 41 99.16 Very High Very High Very High
INFLAMMATION 39 93.88 High High
Aging 1 93.68 High High
Hypoxia 1 92.40 High High
Hyperalgesia 21 88.24 High High
Anaerobic Bacterial Infections 1 76.16 Quite High
Pain 50 76.04 Quite High
Depression 6 69.36 Quite High
Li-fraumeni Syndrome 10 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that NK1 receptors primarily mediated the actions of substance P on spinal motoneurones and that activation of NK2 or NK3 receptors, predominantly found on interneurones, induced motoneuronal depolarization with different firing patterns.
Positive_regulation (activation) of NK2 in spinal associated with substance p
1) Confidence 0.21 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7517026 Disease Relevance 0 Pain Relevance 0.42
These results suggest the presence of NK1, NK2 and NK3 receptors in noxious sensory neurones.
Positive_regulation (presence) of NK2
2) Confidence 0.19 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9507945 Disease Relevance 0.08 Pain Relevance 0.40
Microinjection of receptor-selective tachykinin agonists and antagonists into the NTS of urethane-anaesthetized rats suggests that stimulation of NK1 and NK3 receptors increases tidal volume, whereas NK2 and NK3 receptor activation produces a bradypnoea. 3.
Positive_regulation (activation) of NK2 associated with antagonist and agonist
3) Confidence 0.16 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11071314 Disease Relevance 0.19 Pain Relevance 0.26
Hence, CP-96,345 and SR 48968 highlight a functional role of NK1 and NK2 receptors in spinal sensory neurotransmission.
Positive_regulation (role) of NK2 in spinal
4) Confidence 0.16 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7682180 Disease Relevance 0.23 Pain Relevance 0.35
The rat urinary bladder possesses NK1, NK2 (but not NK3) and 'septide-sensitive' tachykinin receptors coupled to a phospholipase C.
Positive_regulation (possesses) of NK2 in urinary bladder
5) Confidence 0.10 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9243521 Disease Relevance 0 Pain Relevance 0.22
These results further underline the apparent importance of NK2 receptors in spinal nociceptive processing.
Positive_regulation (importance) of NK2 in spinal associated with nociception
6) Confidence 0.09 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8115032 Disease Relevance 0.30 Pain Relevance 0.39
Activation of NK2 is known to promote analgesia [54].
Positive_regulation (Activation) of NK2 associated with analgesia
7) Confidence 0.07 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.74 Pain Relevance 0.69
Undeca and octapeptides containing 2 D-Trp residues in their sequences were slightly more active on the NK-1, than on the NK-2 and NK-3 receptors and showed little selectivity.
Positive_regulation (active) of NK-2 in NK-3
8) Confidence 0.07 Published 1991 Journal Life Sci. Section Abstract Doc Link 1719324 Disease Relevance 0 Pain Relevance 0.17
Undeca and octapeptides containing 2 D-Trp residues in their sequences were slightly more active on the NK-1, than on the NK-2 and NK-3 receptors and showed little selectivity.
Positive_regulation (active) of NK-2 in NK-2
9) Confidence 0.02 Published 1991 Journal Life Sci. Section Abstract Doc Link 1719324 Disease Relevance 0 Pain Relevance 0.17
Induction of LTP at C-fibre-synapses requires co-activation of NK1 and NK2 receptors [9], opening of ionotropic glutamate receptors of the NMDA type [8,12,13], opening of T-type voltage-gated calcium channels [8,12], and activation of group I but not group II or III metabotropic glutamate receptors [31].
Positive_regulation (activation) of NK2 in synapses associated with c fibre, calcium channel, glutamate receptor and long-term potentiation
10) Confidence 0.01 Published 2007 Journal Mol Pain Section Body Doc Link PMC1852298 Disease Relevance 0.21 Pain Relevance 1.14

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