INT15262

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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 3.28
Pain Relevance 10.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
plasma 26
nucleus 4
hindlimb 2
urine 2
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
Intracerebroventricular 14 100.00 Very High Very High Very High
Pain threshold 4 100.00 Very High Very High Very High
medulla 3 100.00 Very High Very High Very High
MU agonist 2 99.98 Very High Very High Very High
antagonist 11 99.96 Very High Very High Very High
Morphine 26 99.84 Very High Very High Very High
narcan 25 99.78 Very High Very High Very High
orphanin 11 99.76 Very High Very High Very High
anesthesia 12 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 5 100.00 Very High Very High Very High
Nociception 2 99.26 Very High Very High Very High
Heart Rate Under Development 1 99.20 Very High Very High Very High
Hypertension 4 98.94 Very High Very High Very High
Volume Depletion And Dehydration 3 96.28 Very High Very High Very High
Diuresis 2 94.84 High High
Vomiting 5 90.32 High High
Paralysis 2 86.64 High High
Body Weight 2 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ANF III had no effect on the basal plasma AVP and OXT concentrations, however, the peptide inhibited the plasma AVP and OXT elevation induced by hyperosmosis (intraperitoneal injection of 2.5% NaCl).
Negative_regulation (inhibited) of Positive_regulation (elevation) of plasma AVP in plasma
1) Confidence 0.58 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2978124 Disease Relevance 0.15 Pain Relevance 0.17
Administration of naloxone before fentanyl prevented the increase of plasma AVP levels during anesthesia and surgery and blunted the elevation of plasma cortisol during surgery.
Negative_regulation (prevented) of Positive_regulation (increase) of plasma AVP in plasma associated with anesthesia and narcan
2) Confidence 0.51 Published 1984 Journal Anesth. Analg. Section Abstract Doc Link 6691560 Disease Relevance 0 Pain Relevance 0.70
The plasma AVP increase in response to PEG-induced hypovolemia was also attenuated significantly and more potently when NPFF was injected into the cisterna magna so that the given drug could be readily accessible to the dorsal medulla where the nucleus of solitary tract is located (10 micrograms/rat; 2.71 +/- 0.14 pg/ml).
Negative_regulation (attenuated) of Positive_regulation (increase) of plasma AVP in nucleus associated with medulla and pressure volume 2 under development
3) Confidence 0.47 Published 1996 Journal Endocrinology Section Abstract Doc Link 8612481 Disease Relevance 0.18 Pain Relevance 0.23
The AVP response induced by icv injection of angiotensin II (100 pmol) was significantly decreased by the simultaneous icv injection of leumorphin (6-600 pmol) in a dose-dependent manner.
Negative_regulation (decreased) of Positive_regulation (induced) of AVP
4) Confidence 0.43 Published 1988 Journal Endocrinology Section Abstract Doc Link 3342763 Disease Relevance 0 Pain Relevance 0.25
The selective AVP V1 receptor antagonist [1-(beta-mercapto-beta,beta-cyclopentamethylene propionic acid), 2-(O-methyl)tyrosine] arg8-vasopressin, which previously blocked the effects of AVP on hindlimb motor and nociceptive function, in these experiments also blocked the AVP-induced increases in arterial pressure and reductions in lumbosacral perfusion.
Negative_regulation (blocked) of Positive_regulation (increases) of AVP in hindlimb associated with nociception and antagonist
5) Confidence 0.43 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2524587 Disease Relevance 0.29 Pain Relevance 0.38
Dexamethasone administration (15 micrograms/kg X day) for 5 days prevented the ADX-induced increase in portal plasma AVP concentrations without significantly changing portal plasma AVP concentrations in intact rats.
Negative_regulation (prevented) of Positive_regulation (increase) of AVP in plasma associated with dexamethasone
6) Confidence 0.43 Published 1986 Journal Endocrinology Section Abstract Doc Link 2938937 Disease Relevance 0 Pain Relevance 0.59
The results showed that (1) pain stimulation increased both NA and AVP concentrations in the PVN perfusion liquid; (2) PVN administration of l-glutamate sodium increased AVP, not NA concentration in the PVN perfusion liquid; (3) AVP or d(CH(2))(5)Tyr(Et)DAVP (AVP-receptor antagonist) neither changed pain threshold, nor influenced NA concentration in the PVN perfusion liquid; (4) Microinjection of NA into PVN could increase pain threshold in a dose-dependent manner, while PVN administration with phentolamine (alpha-receptor antagonist), not propranolol (beta-receptor antagonist) decreased pain threshold; (5) Administration of NA increased AVP concentration, while phentolamine, not propranolol decreased AVP concentration in the PVN perfusion liquid.
Negative_regulation (decreased) of Positive_regulation (increased) of AVP in PVN associated with pain, pain threshold, glutamate and antagonist
7) Confidence 0.43 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19573913 Disease Relevance 0.65 Pain Relevance 0.95
The elevated plasma AVP level in response to short-term hypotension induced by intravenous infusion of sodium nitroprusside was also significantly reduced by i.c.v. administration of L-NAME.
Negative_regulation (reduced) of Positive_regulation (elevated) of AVP in plasma associated with pressure volume 2 under development
8) Confidence 0.43 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014178 Disease Relevance 0.10 Pain Relevance 0.12
kappa-Opioid agonist inhibition of osmotically induced AVP release: preferential action at hypothalamic sites.
Negative_regulation (inhibition) of Positive_regulation (induced) of AVP associated with mu agonist
9) Confidence 0.43 Published 1996 Journal Am. J. Physiol. Section Title Doc Link 8779961 Disease Relevance 0.09 Pain Relevance 0.53
Intracerebroventricular injection of porcine galanin suppressed hypertonic saline-induced increase in plasma AVP in a dose-dependent manner (12.5-100 pmol/rat) at 10 min after the injection.
Negative_regulation (suppressed) of Positive_regulation (increase) of AVP in plasma associated with intracerebroventricular
10) Confidence 0.42 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1719452 Disease Relevance 0 Pain Relevance 0.17
The vasopressin response induced by intracerebroventricular injection of angiotensin II (100 pmol) was significantly suppressed, in a dose-dependent fashion, by the simultaneous intracerebroventricular injection of leumorphin (6, 60, or 600 pmol).
Negative_regulation (suppressed) of Positive_regulation (induced) of vasopressin associated with intracerebroventricular
11) Confidence 0.42 Published 1988 Journal Hypertension Section Abstract Doc Link 3346067 Disease Relevance 0.16 Pain Relevance 0.41
Chloroquine administration was accompanied by a significant increase (p < 0.05) in plasma vasopressin, which was also reversed by L-NAME.
Negative_regulation (reversed) of Positive_regulation (increase) of vasopressin in plasma
12) Confidence 0.42 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490586 Disease Relevance 0 Pain Relevance 0.06
The plasma AVP increase in response to either hyperosmolality [i.p. injection of hypertonic saline (HS) (600 mosml/kg)] or hypovolemia [i.p. injection of polyethylene glycol (PEG)] was also significantly blunted when nociceptin was injected i.c.v.
Negative_regulation (blunted) of Positive_regulation (increase) of AVP in plasma associated with pressure volume 2 under development and orphanin
13) Confidence 0.40 Published 2000 Journal Endocrinology Section Abstract Doc Link 11108256 Disease Relevance 0.28 Pain Relevance 0.69
The plasma AVP increase in response to either hyperosmolality [ip injection of hypertonic saline (HS), 600 mosmol/kg] or hypovolemia [ip injection of polyethylene glycol (PEG)] was also significantly attenuated by an intracerebroventricular injection of TIP39 (HS with 100 pmol/rat TIP39, 2.65 +/- 0.52 pg/ml; vs.
Negative_regulation (attenuated) of Positive_regulation (increase) of AVP in plasma associated with pressure volume 2 under development and intracerebroventricular
14) Confidence 0.38 Published 2003 Journal Endocrinology Section Abstract Doc Link 12810532 Disease Relevance 0.20 Pain Relevance 0.30
These results indicate that in patients undergoing cardiac surgery the neuroendocrine reflex control of plasma AVP levels in relation to changes in arterial pressure is intact, but that the sensitivity of the reflex (i.e. the increase in plasma AVP level for a given fall in arterial pressure) is reduced by the administration of high doses of intravenous morphine.
Negative_regulation (reduced) of Positive_regulation (increase) of AVP in plasma associated with morphine
15) Confidence 0.38 Published 1989 Journal Br J Surg Section Abstract Doc Link 2917257 Disease Relevance 0 Pain Relevance 0.42
Chloroquine administration in paracetamol treated rats induced a significant reduction (p < 0.05) in urine flow rate and a significant increase in plasma vasopressin (p < 0.001).
Negative_regulation (reduction) of Positive_regulation (increase) of vasopressin in plasma associated with paracetamol
16) Confidence 0.36 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649360 Disease Relevance 0.39 Pain Relevance 0.77
Corticosteroid replacement studies in ADX rats indicated that lower doses of dexamethasone attenuated, and higher doses essentially abolished, the expected enhancement of both CRF and vasopressin immunoreactivity after ADX.
Negative_regulation (abolished) of Positive_regulation (enhancement) of vasopressin associated with corticosteroid and dexamethasone
17) Confidence 0.34 Published 1987 Journal J. Neurosci. Section Abstract Doc Link 3553442 Disease Relevance 0 Pain Relevance 0.34
Saralasin, i.v.t., abolished angiotensin-stimulated increase in plasma vasopressin concentration and prevented the residual, but significant, increase in plasma vasopressin concentration in angiotensin-treated rats given enkephalin.
Negative_regulation (prevented) of Positive_regulation (increase) of vasopressin in plasma associated with enkephalin
18) Confidence 0.31 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7229996 Disease Relevance 0 Pain Relevance 0.79
Two-way analysis of variance confirmed that ondansetron significantly decreased the increase in AVP by morphine at 60 and 90 min (P < 0.05).
Negative_regulation (decreased) of Positive_regulation (increase) of AVP associated with morphine
19) Confidence 0.30 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 16192514 Disease Relevance 0.26 Pain Relevance 0.65
One-week SAD rats were characterized by hypertension, tachycardia, increased norepinephrine content, and decreased beta-endorphin and leu-enkephalin content in hypothalamus and medulla oblongata, and increased plasma levels of arginine-vasopressin.
Negative_regulation (decreased) of Positive_regulation (increased) of arginine-vasopressin in plasma associated with medulla, heart rate under development, hypertension and enkephalin
20) Confidence 0.11 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14716211 Disease Relevance 0.35 Pain Relevance 0.42

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