INT152629

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 6.74
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bid) mitochondrion (Bid) cytoplasm (Bid)
Anatomy Link Frequency
cleavage 3
Bid (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diabetic neuropathy 22 99.98 Very High Very High Very High
Pain 44 99.90 Very High Very High Very High
pregabalin 73 99.68 Very High Very High Very High
Inflammatory mediators 6 97.96 Very High Very High Very High
Glutamate 3 90.52 High High
abdominal pain 1 88.96 High High
nud 1 86.88 High High
Potency 1 86.44 High High
imagery 6 82.72 Quite High
Neuropathic pain 2 82.04 Quite High
Disease Link Frequency Relevance Heat
Death 153 100.00 Very High Very High Very High
Apoptosis 153 100.00 Very High Very High Very High
Peripheral Neuropathy 22 99.98 Very High Very High Very High
Injury 39 99.36 Very High Very High Very High
Hypoxia 6 98.44 Very High Very High Very High
INFLAMMATION 27 97.96 Very High Very High Very High
Stress 33 97.12 Very High Very High Very High
Neurodegenerative Disease 3 92.00 High High
Infection 10 91.60 High High
Abdominal Pain 1 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bid is an essential component of most forms of death receptor-mediated apoptosis, and is activated post-translationally via caspase-8-mediated cleavage into a truncated form (tBid) [20,21]. tBid is subsequently myristoylated [22], triggers the activation of Bak or Bax [23,24], and induces cyt-C release from mitochondria.
Positive_regulation (activated) of Bid in cleavage associated with apoptosis and death
1) Confidence 0.46 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.11 Pain Relevance 0.07
Increased activation of Bax and Bid in CCl4 treated rats indicates apoptosis is more in these rats.
Positive_regulation (activation) of Bid associated with apoptosis
2) Confidence 0.45 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.88 Pain Relevance 0.06
Prior treatment of natansnin (both concentrations) reduced the incidence of apoptosis by decreasing the activation of Bax and Bid.
Positive_regulation (activation) of Bid associated with apoptosis
3) Confidence 0.45 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.98 Pain Relevance 0.10
Bid is an essential component of most forms of death receptor-mediated apoptosis, and is activated post-translationally via caspase-8-mediated cleavage into a truncated form (tBid) [20,21]. tBid is subsequently myristoylated [22], triggers the activation of Bak or Bax [23,24], and induces cyt-C release from mitochondria.
Positive_regulation (induces) of tBid in cleavage associated with apoptosis and death
4) Confidence 0.43 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.10 Pain Relevance 0.08
The BH3-only protein Bid can be activated in response to death receptor activation via caspase 8-mediated cleavage into a truncated protein (tBid), which subsequently translocates to mitochondria and induces the release of cytochrome-C.
Positive_regulation (activated) of Bid in cleavage associated with death
5) Confidence 0.40 Published 2007 Journal BMC Cell Biol Section Abstract Doc Link PMC1808451 Disease Relevance 0.81 Pain Relevance 0.07
CCl4 treatment significantly increased the levels of apoptotic proteins such as caspases-3, PARP, Bax, Bid and cytochrome C and also increased the levels of inflammatory mediators iNos and Cox-2.
Positive_regulation (increased) of Bid associated with inflammatory mediators and apoptosis
6) Confidence 0.15 Published 2010 Journal BMC Pharmacol Section Abstract Doc Link PMC2967507 Disease Relevance 0.79 Pain Relevance 0.09
Six patients received CP-690 550 5 mg twice daily (BID), 6 patients received 15 mg BID, 10 patients received 30 mg BID, and 6 patients received placebo.
Positive_regulation (received) of BID
7) Confidence 0.11 Published 2008 Journal Am. J. Transplant. Section Abstract Doc Link 18557720 Disease Relevance 0.44 Pain Relevance 0.18
In addition, TID dosing was used in the first four trials, whereas the three most recent trials of pregabalin in painful DPN used BID dosing.
Positive_regulation (used) of BID associated with pain, pregabalin and diabetic neuropathy
8) Confidence 0.03 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2453685 Disease Relevance 0.63 Pain Relevance 1.14

General Comments

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