INT152643

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.20
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IFIH1) nucleus (IFIH1) intracellular (IFIH1)
helicase activity (IFIH1) DNA binding (IFIH1) cytoplasm (IFIH1)
Anatomy Link Frequency
eye 2
IFIH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 3 90.20 High High
agonist 2 89.64 High High
Serotonin 1 88.64 High High
headache 1 74.84 Quite High
Pain 13 74.44 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Pain management 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 1 100.00 Very High Very High Very High
Skin Cancer 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Apoptosis 1 100.00 Very High Very High Very High
Chronic Disease 93 99.68 Very High Very High Very High
Infection 64 96.44 Very High Very High Very High
Disease 203 94.88 High High
Lymphatic Filariasis 267 94.56 High High
Hydrocele 78 92.48 High High
Lymphedema 84 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDA produced a significant increase in closed-eye visions (CEVs), with considerable individual variation.
Positive_regulation (increase) of Gene_expression (produced) of MDA in eye
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2996283 Disease Relevance 0.25 Pain Relevance 0.13
All the protected individuals in these two ‘benefiting populations’ need not themselves have been directly treated during the MDA, as high MDA coverage in at-risk populations will drastically reduce the rate of transmission and, therefore, infection in untreated individuals as well [18], [19].
Positive_regulation (coverage) of Gene_expression (coverage) of MDA associated with infection
2) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.27 Pain Relevance 0
Chronic disease regression and reversal with MDA
Positive_regulation (reversal) of Gene_expression (reversal) of MDA associated with chronic disease
3) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 0.79 Pain Relevance 0
All the protected individuals in these two ‘benefiting populations’ need not themselves have been directly treated during the MDA, as high MDA coverage in at-risk populations will drastically reduce the rate of transmission and, therefore, infection in untreated individuals as well [18], [19].
Positive_regulation (coverage) of Gene_expression (coverage) of MDA associated with infection
4) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.27 Pain Relevance 0
Increased expression of the type I IFN response genes for tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), melanoma-derived antigen 5 (MDA-5), IFN-gamma-inducible protein 10 (IP-10), galectin 3 soluble binding protein (LGals3BP) and IFN response factor 7 (IRF7) was confirmed by quantitative RT-PCR.
Positive_regulation (Increased) of Gene_expression (expression) of MDA-5 associated with necrosis, cancer, skin cancer and apoptosis
5) Confidence 0.15 Published 2008 Journal J. Gen. Virol. Section Abstract Doc Link 18559930 Disease Relevance 1.62 Pain Relevance 0.15

General Comments

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