INT15265

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Context Info
Confidence 0.54
First Reported 1991
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.80
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adra2c) cytoplasm (Adra2c) signal transducer activity (Adra2c)
Anatomy Link Frequency
dorsal root ganglion 2
IMCD 1
Adra2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 13 99.12 Very High Very High Very High
dorsal root ganglion 10 99.02 Very High Very High Very High
Clonidine 14 98.80 Very High Very High Very High
antagonist 2 97.36 Very High Very High Very High
Brush evoked pain 2 95.64 Very High Very High Very High
nociceptor 4 94.56 High High
Spinal nerve ligature 2 94.56 High High
qutenza 4 93.64 High High
Pain 2 84.04 Quite High
Catecholamine 2 74.52 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 10 99.02 Very High Very High Very High
Neuropathic Pain 4 95.64 Very High Very High Very High
Aids-related Complex 3 95.32 Very High Very High Very High
Nervous System Injury 2 91.88 High High
Hypersensitivity 2 88.36 High High
Pain 2 84.04 Quite High
Injury 2 75.04 Quite High
Pressure Volume 2 Under Development 1 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that rat IMCD cells in primary culture express functional alpha 2-adrenoceptors of the alpha 2B-subtype.
Gene_expression (express) of alpha 2B-subtype in IMCD
1) Confidence 0.54 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1719824 Disease Relevance 0.15 Pain Relevance 0.38
Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine.
Gene_expression (co-expression) of alpha2C-adrenoceptor in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and clonidine
2) Confidence 0.30 Published 2005 Journal Pain Section Title Doc Link 15661448 Disease Relevance 0.75 Pain Relevance 0.87
In normal and sham controls, about one-third of DRG neurons were TRPV-1-immunoreactive (IR), one half were alpha2C-adrenoceptor-IR and one-fourth co-expressed both.
Gene_expression (co-expressed) of alpha2C-adrenoceptor-IR in DRG associated with dorsal root ganglion
3) Confidence 0.23 Published 2005 Journal Pain Section Abstract Doc Link 15661448 Disease Relevance 0.75 Pain Relevance 1.09
Though expression of mRNA of alpha2B-, as well as alpha2A- and alpha2C-adrenoceptor subtypes was demonstrated in gastric mucosa of the rat, the hydrophilic ST-91, given peripherally (orally, subcutaneously), failed to exert mucosal protection, in contrast with clonidine and rilmenidine which were also effective.
Gene_expression (expression) of alpha2C-adrenoceptor associated with clonidine
4) Confidence 0.18 Published 2007 Journal Neurochem. Int. Section Abstract Doc Link 17707950 Disease Relevance 0.08 Pain Relevance 0.33
There is large interindividual variability in response to the selective alpha(2)-AR agonist dexmedetomidine, and neither ethnicity nor ADRA2C and GNB3 genotypes contribute to it.
Neg (neither) Gene_expression (contribute) of ADRA2C associated with agonist
5) Confidence 0.16 Published 2008 Journal Hypertension Section Abstract Doc Link 18071056 Disease Relevance 0.07 Pain Relevance 0.16

General Comments

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