INT152666

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.52
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREBBP) small molecule metabolic process (CREBBP) protein complex assembly (CREBBP)
DNA binding (CREBBP) cytoplasm (CREBBP) signal transducer activity (CREBBP)
CREBBP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 87.92 High High
cINOD 26 5.00 Very Low Very Low Very Low
aspirin 14 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 36 87.04 High High
Colon Cancer 20 85.52 High High
Pain 1 72.04 Quite High
Disease 37 71.80 Quite High
INFLAMMATION 5 71.44 Quite High
Diabetes Mellitus 5 70.56 Quite High
Cancer 162 62.72 Quite High
Rheumatoid Arthritis 16 40.64 Quite Low
Colorectal Cancer 36 5.00 Very Low Very Low Very Low
Familial Adenomatous Polyposis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The compound (ICG-001; Figure 4) described by Kahn et al. showed specific affinity and inhibition of CBP, and proved effective in preventing CBP-mediated transcriptional activation and ?
Negative_regulation (inhibition) of CBP
1) Confidence 0.06 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.24 Pain Relevance 0.06
-catenin/Tcf4 transcriptional pathway by inhibiting cyclic AMP response element-binding protein (CBP) (Figure 4) [70, 171].
Negative_regulation (inhibiting) of CBP
2) Confidence 0.06 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0.09
RESULTS: RRME inhibited both p300 and CBP (60-70% at 100 microg/ml) activity.
Negative_regulation (inhibited) of CBP
3) Confidence 0.03 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18562138 Disease Relevance 0.29 Pain Relevance 0

General Comments

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