INT152667

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.72
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 89.72 High High
antagonist 4 89.16 High High
withdrawal 28 85.84 High High
cytokine 1 85.44 High High
imagery 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 10 84.32 Quite High
Prostate Cancer 18 71.88 Quite High
Pain 1 63.80 Quite High
Disease 10 63.56 Quite High
INFLAMMATION 1 63.20 Quite High
Body Weight 6 62.80 Quite High
Diabetes Mellitus 1 62.32 Quite High
Delayed Puberty 1 50.20 Quite High
Opiate Addiction 2 5.56 Low Low
Metastasis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional activity of the androgen receptor, which was inhibited in the presence of bicalutamide, was then turned on.


Negative_regulation (inhibited) of Transcription (activity) of androgen receptor
1) Confidence 0.42 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.30 Pain Relevance 0.24
RRME treatment also decreased transcription of AR regulated genes and also reduced histone H3 and AR acetylation in the promoters of prostate-specific antigen (PSA) and beta-2-microglobulin (B2M).
Negative_regulation (decreased) of Transcription (transcription) of AR
2) Confidence 0.34 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18562138 Disease Relevance 0.25 Pain Relevance 0
AR mRNA and protein levels were reduced (Figures 2, 3).
Negative_regulation (reduced) of Transcription (levels) of AR
3) Confidence 0.07 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0.17 Pain Relevance 0

General Comments

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