INT152668

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2008
Negated 2
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 7.78
Pain Relevance 9.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EP300) transferase activity, transferring acyl groups (EP300) DNA binding (EP300)
cytoplasm (EP300) nucleolus (EP300) nucleus (EP300)
EP300 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 354 99.98 Very High Very High Very High
methadone 328 99.12 Very High Very High Very High
alcohol 463 98.72 Very High Very High Very High
opiate 318 98.64 Very High Very High Very High
addiction 478 98.52 Very High Very High Very High
Central nervous system 32 98.00 Very High Very High Very High
cocaine 480 97.16 Very High Very High Very High
drug abuse 116 96.56 Very High Very High Very High
cannabis 76 89.92 High High
Neurotransmitter 34 83.20 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 150 99.84 Very High Very High Very High
Sleep Disorders 130 99.72 Very High Very High Very High
Congenital Anomalies 75 99.60 Very High Very High Very High
Alcohol-related Disorders 1 99.44 Very High Very High Very High
Opiate Addiction 111 98.52 Very High Very High Very High
Mental Disorders 63 98.40 Very High Very High Very High
Drug Dependence 704 96.56 Very High Very High Very High
Conduct Disorder 26 95.56 Very High Very High Very High
Post-traumatic Stress Disorder 75 94.40 High High
Attention Deficit Hyperactivity Disorder 163 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recently, Neuhaus et al. (2006), using an auditory oddball paradigm, reported persistent P300 amplitude reduction in smokers and furthermore, even in former smokers [18].
Negative_regulation (reduction) of P300 associated with nicotine addiction
1) Confidence 0.38 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.55 Pain Relevance 1.00
Results from these studies indicate that chronic nicotine consumption is associated with P300 amplitude reduction, which may confound results when comparing P300 results of nicotine dependent opiate addicts to those of non-smoking control subjects.
Negative_regulation (reduction) of P300 associated with nicotine addiction, nicotine and opiate
2) Confidence 0.38 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.54 Pain Relevance 1.07
Previous studies on the P300 in opiate addicts used small sample sizes and it remains unclear whether the P300 is unaffected in a larger group of methadone substituted opiate addicts when compared to controls.
Neg (unaffected) Spec (whether) Negative_regulation (unaffected) of P300 associated with methadone and opiate
3) Confidence 0.38 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.45 Pain Relevance 1.25
Chronic nicotine consumption has been found to be associated with P300 amplitude reduction using a visual oddball paradigm in a large sample of current smokers when compared to subjects who never smoked or those who had terminated smoking [17].
Negative_regulation (reduction) of P300 associated with nicotine addiction and nicotine
4) Confidence 0.38 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.50 Pain Relevance 1.01
However it remains unclear, whether chronic nicotine reduces P300 amplitudes or whether subjects with lower P300 amplitudes are more prone to nicotine and use it as some form of self medication.
Spec (whether) Negative_regulation (reduces) of P300 associated with nicotine
5) Confidence 0.37 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.68 Pain Relevance 1.01
Nicotine users showed largely reduced P300 amplitudes at the three electrode sites under investigation.
Negative_regulation (reduced) of P300 associated with nicotine
6) Confidence 0.37 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.23 Pain Relevance 0.82
Given the current collection of empirical observations, it seems reasonable to conclude that the amplitude reduction of N1 and P300 after SD and the amplitude enhancement of those components after a dose of caffeine are both related to changes in attention and thus to changes in sensory processing, albeit in opposite directions.
Negative_regulation (reduction) of P300 associated with sleep disorders
7) Confidence 0.09 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.32 Pain Relevance 0.03
RESULTS: RRME inhibited both p300 and CBP (60-70% at 100 microg/ml) activity.
Negative_regulation (inhibited) of p300
8) Confidence 0.08 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18562138 Disease Relevance 0.29 Pain Relevance 0
Across all the patient groups, the P300 was significantly reduced in amplitude relative to the P300 ERPs recorded from individuals with no history of alcohol or drug dependence.
Negative_regulation (reduced) of P300 associated with drug dependence, addiction and alcohol
9) Confidence 0.08 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.45 Pain Relevance 0.49
Across all the patient groups, the P300 was significantly reduced in amplitude relative to P300 ERPs recorded from individuals with no history of alcohol or drug dependence.
Negative_regulation (reduced) of P300 associated with drug dependence, addiction and alcohol
10) Confidence 0.08 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.37 Pain Relevance 0.66
Thus, the reviewed findings support the hypothesis that addicted subjects may manifest a P300 amplitude reduction and qEEG abnormalities as a trait reflecting the CNS disinhibition, which may be a predisposing factor for addiction liability, resistance to drug habit extinction, and relapse vulnerability.
Negative_regulation (reduction) of P300 associated with addiction, congenital anomalies, central nervous system and recurrence
11) Confidence 0.08 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 1.22 Pain Relevance 0.42
The P300 reduction and abnormal qEEG patterns are seen in mental disorders that often are comorbid with substance abuse, such as conduct disorder (Bauer and Hesselbrock 1999, 2001), ADHD (Bauer 1997; O’Connor et al. 1994), and bipolar or major affective disorder (Friedman and Squires-Wheeler 1994).
Negative_regulation (reduction) of P300 associated with mental disorders, conduct disorder, affective disorder, drug abuse and attention deficit hyperactivity disorder
12) Confidence 0.06 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 1.15 Pain Relevance 0.50
Abstinent heroin addicts exhibited a significant reduction of the P300 amplitude at the central frontal region, relative to the other two groups.
Negative_regulation (reduction) of P300
13) Confidence 0.06 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.34 Pain Relevance 0.46
Indeed, the P300 amplitude of the ERPs is reduced in the sons of alcoholic fathers, with no previous exposure to alcohol [97].
Negative_regulation (reduced) of P300 associated with alcohol
14) Confidence 0.06 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691669 Disease Relevance 0.64 Pain Relevance 0.31
only considered the standard tone measurements and not the deviant and the P300
Neg (not) Negative_regulation (considered) of P300
15) Confidence 0.02 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2233897 Disease Relevance 0.05 Pain Relevance 0

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