INT152670

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.04
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HAT1) nucleolus (HAT1) nucleus (HAT1)
transferase activity, transferring acyl groups (HAT1) cytoplasm (HAT1)
HAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 99.20 Very High Very High Very High
cytokine 8 98.12 Very High Very High Very High
dexamethasone 1 92.32 High High
corticosteroid 4 65.12 Quite High
agonist 16 50.00 Quite Low
metalloproteinase 14 50.00 Quite Low
cINOD 1 21.84 Low Low
depression 9 5.00 Very Low Very Low Very Low
antiepileptic Drug 7 5.00 Very Low Very Low Very Low
Lamotrigine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 53 99.74 Very High Very High Very High
INFLAMMATION 18 99.20 Very High Very High Very High
Repression 6 90.56 High High
Shock 1 77.76 Quite High
Breast Cancer 6 59.04 Quite High
Pain 3 51.00 Quite High
Disease 31 50.76 Quite High
Toxicity 9 50.00 Quite Low
Diabetes Mellitus 4 49.52 Quite Low
Apoptosis 15 45.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of HAT activity is elevated in patients with asthma, and HDAC activity is reduced in bronchial biopsies, which may contribute to local proinflammatory cytokine production.20 Glucocorticoids switch off inflammatory genes in those with asthma by directly inhibiting HAT activity and by recruiting HDAC2 to activate nuclear factor ?
Negative_regulation (inhibiting) of HAT associated with asthma, inflammation and cytokine
1) Confidence 0.07 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892049 Disease Relevance 0.69 Pain Relevance 0.25
This anchors the corepressors and prevents their release upon proinflammatory stimulation, thereby blocking recruitment of coactivator complexes with HAT activity.
Negative_regulation (recruitment) of HAT
2) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.14 Pain Relevance 0.07
CONCLUSION: These results demonstrate RRME is a potent HAT inhibitor, which reduced AR and histone acetylation leading to decreased AR-mediated transcription and reduced LNCaP cell growth.


Negative_regulation (inhibitor) of HAT
3) Confidence 0.01 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18562138 Disease Relevance 0.15 Pain Relevance 0
However, through HDACi activity, VPA enables methylated DNA to be more accessible, which is confirmed by the observation that inhibition of HAT diminishes the demethylation effect triggered by VPA [23, 24].
Negative_regulation (inhibition) of HAT
4) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.06 Pain Relevance 0

General Comments

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