INT152681

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Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 23.06
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PDPN) signal transduction (PDPN) cell morphogenesis (PDPN)
plasma membrane (PDPN) embryo development (PDPN) cell cycle (PDPN)
Anatomy Link Frequency
lung 8
lymph node 1
platelet 1
podocytes 1
lymphatic vessels 1
PDPN (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 1 95.84 Very High Very High Very High
Kinase C 27 75.72 Quite High
Inflammation 1 68.24 Quite High
fibrosis 6 29.08 Quite Low
qutenza 4 10.00 Low Low
anesthesia 27 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2239 99.84 Very High Very High Very High
Lung Cancer 27 99.82 Very High Very High Very High
Skin Cancer 459 99.78 Very High Very High Very High
Malignant Neoplastic Disease 390 99.52 Very High Very High Very High
Adenocarcinoma 27 99.24 Very High Very High Very High
Metastasis 680 97.80 Very High Very High Very High
Germ Cell And Embryonal Neoplasms 27 96.32 Very High Very High Very High
Respiratory Failure 27 94.60 High High
Death 27 93.52 High High
Pressure And Volume Under Development 33 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blood and lymphatic vessels were studied by Ulex europaeus agglutinin-1, human podoplanin, human vascular endothelial growth factor-C (H-VEGF-C) and alpha-actin immunoreactivities.
Gene_expression (studied) of podoplanin in lymphatic vessels
1) Confidence 0.65 Published 2009 Journal J. Cutan. Pathol. Section Body Doc Link 18564281 Disease Relevance 0 Pain Relevance 0
Regarding the negative data obtained from the migration assay, we performed additional experiments to indicate a positive control, which revealed that stable overexpression of exogenous podoplanin could promote the migration activity in SAS cells, an oral SCC cell line (additional file 1).
Gene_expression (overexpression) of podoplanin associated with skin cancer
2) Confidence 0.65 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.21 Pain Relevance 0
Podoplanin is also expressed in a variety of non-neoplastic cells such as podocytes and alveolar type-I cells [18-23].
Gene_expression (expressed) of Podoplanin in podocytes
3) Confidence 0.65 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 1.15 Pain Relevance 0
As described above, podoplanin has the potential to induce EMT [29], so forced and long-term expression of podoplanin in our experimental conditions may cause several phenotypic changes of EBC-1 cells, resulting in the increased level of total JNK.
Gene_expression (expression) of podoplanin
4) Confidence 0.65 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.21 Pain Relevance 0.03
First, we confirmed exogenous podoplanin expression in tumor tissue.
Gene_expression (expression) of podoplanin associated with cancer
5) Confidence 0.65 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 1.27 Pain Relevance 0
Current immunohistochemical studies have revealed the expression of podoplanin in a variety of malignant cells.
Gene_expression (expression) of podoplanin associated with malignant neoplastic disease
6) Confidence 0.65 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.86 Pain Relevance 0
In fact, the function-related data were often from experiments using malignant cell lines that lacked podoplanin expression in actual human lesions.
Neg (lacked) Gene_expression (expression) of podoplanin associated with malignant neoplastic disease
7) Confidence 0.65 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.78 Pain Relevance 0
Using stable lung SCC cell line-derived transformants exogenously expressing podoplanin, we herein found direct evidence suggesting the role of podoplanin in experimental tumor progression.
Gene_expression (expressing) of podoplanin in lung associated with cancer and skin cancer
8) Confidence 0.65 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.61 Pain Relevance 0
As shown in Figure 3A, human podoplanin expression was immunohistochemically detected at the tumor cell surface in EBC1-P4-derived tumor tissue.
Gene_expression (expression) of podoplanin associated with cancer
9) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 1.28 Pain Relevance 0
For example, since it has been immunohistochemically reported that almost all adenocarcinomas cells, including lung cancer, hardly express podoplanin [22,23], the evidence from experimental studies on podoplanin functions using such cell lines/animal models may be rather different from the pathophysiological roles it plays in human malignancies.
Gene_expression (express) of podoplanin in lung associated with adenocarcinoma and lung cancer
10) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.66 Pain Relevance 0
For example, Yuan et al. and Chuang et al. demonstrated that a higher expression level of podoplanin in cancer cells significantly correlated with poor prognosis and a higher incidence of lymph node metastasis in head and neck SCC [33,34].
Gene_expression (expression) of podoplanin in head associated with cancer, skin cancer and metastasis
11) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 1.40 Pain Relevance 0
In the case of SCCs, podoplanin is mainly expressed in peripheral cancer cells in solid nests [22,34,36].
Gene_expression (expressed) of podoplanin associated with cancer
12) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.87 Pain Relevance 0
By contrast, as shown in Figure 6B, not only the phosphorylated JNK but also the total JNK levels were apparently increased in stable transformants exogenously expressing podoplanin.
Gene_expression (expressing) of podoplanin
13) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.24 Pain Relevance 0.04
Protein expression of exogenous podoplanin was confirmed by Western blot analysis (Figure 1B).
Gene_expression (expression) of podoplanin
14) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.33 Pain Relevance 0
To enhance the credibility and universality of the podoplanin-JNK-VEGF-C axis in LSCCs, we further performed in vitro examinations, using H157, a lung SCC cell line with podoplanin expression (Figure 1A).
Gene_expression (expression) of podoplanin in lung associated with skin cancer
15) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.16 Pain Relevance 0
Recently, podoplanin has been reported to be expressed in a variety of malignant tumor cells, such as squamous cell carcinoma, methothelioma, and germ cell tumors [22,26], and evidence suggesting the involvement of podoplanin in malignant potential from various studies has accumulated: 1) Podoplanin can alter cell morphology and motility, by which tumor invasive/migratory activity is promoted [27,28]; 2) Podoplanin can induce the epithelial-mesenchymal transition [29]; and 3) Podoplanin can induce platelet activation/aggregation mediated by its platelet aggregation-stimulating (PLAG) domain, resulting in a greater ability to achieve hematogenous metastasis of circulating tumor cells [30-32].
Gene_expression (expressed) of podoplanin in platelet associated with malignant neoplastic disease, cancer, germ cell and embryonal neoplasms, skin cancer and metastasis
16) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 1.15 Pain Relevance 0
Podoplanin suppresses endogenous VEGF-C but not other lymphangiogenesis-related growth factor gene expressions in vivo and in vitro
Gene_expression (expressions) of Podoplanin
17) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.75 Pain Relevance 0
RT-PCR revealed that only EBC-1 cells showed no podoplanin expression (Figure 1A).
Neg (no) Gene_expression (expression) of podoplanin
18) Confidence 0.50 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.97 Pain Relevance 0
Consequently, experimental studies should be designed with human cell lines that actually express podoplanin in human malignancies in order to understand its true role in human pathology.
Gene_expression (express) of podoplanin
19) Confidence 0.50 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.41 Pain Relevance 0.03
The morphological appearances were supported by the results of Western blot analysis, which demonstrated that the phosphorylated levels of ERM molecules (ezrin/radixin/moesin), which are implicated in cellular actin cytoskeleton rearrangement, were not affected by podoplanin overexpression in EBC-1 cells (Figure 1F).
Gene_expression (overexpression) of podoplanin
20) Confidence 0.50 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.27 Pain Relevance 0

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