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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.30
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (H2-Ab1) plasma membrane (H2-Ab1) intracellular (H2-Ab1)
transcription factor binding (H2-Ab1)
Anatomy Link Frequency
blood 2
CD86 2
aortas 2
H2-Ab1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 37 87.88 High High
antagonist 8 84.52 Quite High
cytokine 16 80.44 Quite High
imagery 2 71.84 Quite High
Multiple sclerosis 24 66.48 Quite High
rheumatoid arthritis 38 56.56 Quite High
addiction 1 53.12 Quite High
cINOD 2 50.00 Quite Low
chemokine 1 35.28 Quite Low
Inflammatory response 1 31.40 Quite Low
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 2 100.00 Very High Very High Very High
Cancer 10 98.84 Very High Very High Very High
Adhesions 14 95.80 Very High Very High Very High
Autoimmune Disease 4 94.44 High High
Diabetes Mellitus 136 93.04 High High
Acute-phase Reaction 2 92.32 High High
INFLAMMATION 42 87.88 High High
Aging 10 82.28 Quite High
Necrosis 3 81.48 Quite High
Sarcoma 1 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KP at 5% or 10% clearly decreased the PCl-augmented expression of major histocompatibility complex class II and CD86 on LCs.
Negative_regulation (decreased) of Gene_expression (expression) of histocompatibility complex class II in CD86
1) Confidence 0.34 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18565185 Disease Relevance 0 Pain Relevance 0
-receptor 2 expression on peripheral blood mononuclear cells; downregulation of major histocompatibility complex class II expression on virus-infected cells and tumour cells; activation of natural killer cells; downregulation of several adhesion molecules; and enhancement of soluble adhesion molecules in serum.
Negative_regulation (downregulation) of Gene_expression (expression) of major histocompatibility complex class II in blood associated with cancer and adhesions
2) Confidence 0.13 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.38 Pain Relevance 0.34
These findings are in agreement with previous studies stating that the efficiency of the IAB is limited in highly compliant aortas.24
Negative_regulation (limited) of Gene_expression (efficiency) of IAB in aortas
3) Confidence 0.10 Published 2010 Journal The Journal of Thoracic and Cardiovascular Surgery Section Body Doc Link PMC2891860 Disease Relevance 0.06 Pain Relevance 0
They also were able to detect a significant increase in fibrinogen (P= 0.005) and C-reactive protein levels (P= 0.025) in patients with high levels of GAD 65 and/or IA-2 autoantibodies as compared with antibody negative patients and control subjects. [104]
Negative_regulation (detect) of Gene_expression (autoantibodies) of IA-2 associated with generalized anxiety disorder
4) Confidence 0.02 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.86 Pain Relevance 0.12

General Comments

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