INT152696

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.35
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 26 99.68 Very High Very High Very High
spinal dorsal horn 6 85.04 High High
c fibre 6 81.48 Quite High
Pain 2 78.60 Quite High
Disease Link Frequency Relevance Heat
Li-fraumeni Syndrome 2 98.04 Very High Very High Very High
Pain 2 78.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF-induced LTP was completely abolished by the protein synthesis inhibitor (anisomycin), by N-methyl-D-aspartate (NMDA) receptor blocker (MK-801), by extracellular signal-regulated protein kinase (ERK) inhibitor (PD98059) or by p38 mitogen-activated protein kinase (MAPK) inhibitor (SB203580) but not by c-Jun N-terminal kinase (JNK) inhibitor (SP600125).
Negative_regulation (abolished) of Neg (not) Negative_regulation (inhibitor) of c-Jun N-terminal kinase associated with long-term potentiation
1) Confidence 0.32 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18565512 Disease Relevance 0.18 Pain Relevance 1.00
BDNF-induced LTP was completely abolished by the protein synthesis inhibitor (anisomycin), by N-methyl-D-aspartate (NMDA) receptor blocker (MK-801), by extracellular signal-regulated protein kinase (ERK) inhibitor (PD98059) or by p38 mitogen-activated protein kinase (MAPK) inhibitor (SB203580) but not by c-Jun N-terminal kinase (JNK) inhibitor (SP600125).
Negative_regulation (abolished) of Neg (not) Negative_regulation (inhibitor) of JNK associated with long-term potentiation
2) Confidence 0.32 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18565512 Disease Relevance 0.18 Pain Relevance 1.00

General Comments

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