INT152699

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.22
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 1
Bdnf (Rattus norvegicus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 126 100.00 Very High Very High Very High
fluoxetine 99 98.60 Very High Very High Very High
antidepressant 66 97.66 Very High Very High Very High
Hippocampus 57 97.60 Very High Very High Very High
depression 9 90.40 High High
c fibre 3 82.76 Quite High
Pain 4 79.88 Quite High
spinal dorsal horn 3 78.84 Quite High
Glutamate 3 72.20 Quite High
monoamine 3 13.84 Low Low
Disease Link Frequency Relevance Heat
Li-fraumeni Syndrome 1 99.32 Very High Very High Very High
Aids-related Complex 112 99.20 Very High Very High Very High
Stress 13 91.60 High High
Depression 9 90.40 High High
Pain 4 79.88 Quite High
Cognitive Disorder 17 70.00 Quite High
Urological Neuroanatomy 9 46.24 Quite Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Amnesia 3 5.00 Very Low Very Low Very Low
Affective Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF-induced LTP was completely abolished by the protein synthesis inhibitor (anisomycin), by N-methyl-D-aspartate (NMDA) receptor blocker (MK-801), by extracellular signal-regulated protein kinase (ERK) inhibitor (PD98059) or by p38 mitogen-activated protein kinase (MAPK) inhibitor (SB203580) but not by c-Jun N-terminal kinase (JNK) inhibitor (SP600125).
BDNF Positive_regulation (induced) of LTP associated with long-term potentiation
1) Confidence 0.05 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18565512 Disease Relevance 0.18 Pain Relevance 0.97
Chronic antidepressant treatment leads to enhanced TrkB signaling, CREB activation [20, 59–61], and transcription of genes associated with BDNF-induced LTP.
BDNF Positive_regulation (induced) of LTP associated with antidepressant and long-term potentiation
2) Confidence 0.03 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0 Pain Relevance 0.49
This study demonstrates that chronic, but not acute, administration of fluoxetine leads to brain-region specific upregulation of genes associated with BDNF-induced LTP and HFS-induced LTP in the adult
BDNF Positive_regulation (induced) of LTP in brain associated with long-term potentiation and fluoxetine
3) Confidence 0.03 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.07 Pain Relevance 0.67
necessary for the consolidation of BDNF-LTP and HFS-induced LTP [11, 12].
BDNF-LTP Positive_regulation (induced) of LTP associated with long-term potentiation
4) Confidence 0.03 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.58 Pain Relevance 0.72
BDNF-induced LTP in the DG requires Arc synthesis, which serves to stabilize
BDNF Positive_regulation (induced) of LTP associated with aids-related complex and long-term potentiation
5) Confidence 0.02 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.39 Pain Relevance 0.10

General Comments

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