INT152714

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.23
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PISD) lyase activity (PISD)
Anatomy Link Frequency
visceral 1
neurons 1
PISD (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal column 124 100.00 Very High Very High Very High
Dorsal horn 10 97.92 Very High Very High Very High
halothane 12 96.64 Very High Very High Very High
isoflurane 16 96.20 Very High Very High Very High
Spinal cord 44 94.84 High High
Pain management 2 92.68 High High
Visceral pain 52 91.20 High High
analgesia 6 86.76 High High
Opioid 4 80.80 Quite High
Antinociceptive 22 74.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 66 98.40 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

54 93.04 High High
Cancer 8 91.60 High High
Reprotox - General 1 4 74.68 Quite High
Pain 8 31.32 Quite Low
Hypoxia 2 12.80 Low Low
Disease 2 8.36 Low Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Unconsciousness 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a subgroup analysis of women with irritability as their main PMS symptom cluster, the reduction of PSD was even more pronounced (P<0.001).
Negative_regulation (reduction) of PSD
1) Confidence 0.57 Published 2008 Journal Adv Ther Section Body Doc Link 18568441 Disease Relevance 0.07 Pain Relevance 0
CONCLUSION: Femal treatment reduced PSD to a significant degree, particularly in women with irritability as their main PMS symptom.
Negative_regulation (reduced) of PSD
2) Confidence 0.42 Published 2008 Journal Adv Ther Section Body Doc Link 18568441 Disease Relevance 0.05 Pain Relevance 0
Investigation of inhibition of the PSDC pathway by general anesthetics will identify a neurobiological mechanism of general anesthetic action and should help in the development of novel therapeutic strategies for visceral pain management.
Negative_regulation (inhibition) of PSDC in visceral associated with pain management and dorsal column
3) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.46 Pain Relevance 0.92
It may suggest the possibility that PSDC neurons may be more vulnerably depressed by general anesthetics than neurons in superficial dorsal horn, since PSDC neurons are predominantly located in the vicinity of central canal in the spinal gray matter [84].
Negative_regulation (depressed) of PSDC in neurons associated with dorsal horn and dorsal column
4) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.15 Pain Relevance 1.37

General Comments

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