INT152720

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.71
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv2) plasma membrane (Trpv2) intracellular (Trpv2)
transmembrane transport (Trpv2) cytoplasm (Trpv2)
Anatomy Link Frequency
neurons 1
cerebral cortex 1
lamina 1
head 1
Trpv2 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 18 96.64 Very High Very High Very High
cerebral cortex 8 95.32 Very High Very High Very High
Neuropeptide 4 92.88 High High
neuropeptide release 4 82.40 Quite High
Pain 368 81.12 Quite High
qutenza 94 80.64 Quite High
Dorsal column 8 70.92 Quite High
Neuropathic pain 28 68.48 Quite High
Thermal hyperalgesia 36 67.60 Quite High
depression 4 67.36 Quite High
Disease Link Frequency Relevance Heat
Nociception 68 99.12 Very High Very High Very High
Asthma 5 84.16 Quite High
Cough 13 83.84 Quite High
Urticaria 4 82.88 Quite High
INFLAMMATION 58 82.76 Quite High
Pain 384 81.12 Quite High
Coronary Heart Disease 4 80.60 Quite High
Stress Incontinence 4 78.84 Quite High
Neuropathic Pain 84 68.48 Quite High
Anxiety Disorder 8 68.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our finding of the presence of TRPV1 and TRPV2 in the ORNs, as well as in nerve fibers in the lamina propria, suggests that these TRP channels play a vital part in chemosensation by OE.
Localization (presence) of TRPV2 in lamina associated with trp channel
1) Confidence 0.69 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.06 Pain Relevance 0.23
TRPV1 and TRPV2 were often co-localized with substance P, while the co-localization of substance P and TRPV3 was rare and TRPV4 was not co-localized with substance P.


Localization (co-localized) of TRPV2
2) Confidence 0.67 Published 2008 Journal Acta Otolaryngol. Section Body Doc Link 18568506 Disease Relevance 0.25 Pain Relevance 0
These regulatory mechanisms that induce membrane localization of TRPV2 seem to be important regulation mechanisms for TRPV2 activation.


Localization (localization) of TRPV2
3) Confidence 0.48 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.41 Pain Relevance 0.27
Translocation of TRPV2 from intracellular locations to plasma membrane required for its activation is regulated by insulin-like growth factor-I (IGF-I) [99]; A-kinase anchoring proteins (AKAP)/cAMP/protein kinase A (PKA) mediated phosphorylation [197]; G-protein coupled receptor ligands like neuropeptide head activator (HA) via phosphatidylinositol 3-kinase (PI3-K) andof the Ca2+/calmodulin-dependent kinase (CAMK) signaling [17].
Localization (Translocation) of TRPV2 in head associated with neuropeptide
4) Confidence 0.48 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.47 Pain Relevance 0.23
In the brain, TRPV2 is localized to hypothalamic paraventricular, suprachiasmatic, supraoptic nuclei, oxytocinergic and vasopressinergic neurons and cerebral cortex [116].
Localization (localized) of TRPV2 in cerebral cortex associated with cerebral cortex
5) Confidence 0.45 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.76 Pain Relevance 0.40
In the brain, TRPV2 is localized to hypothalamic paraventricular, suprachiasmatic, supraoptic nuclei, oxytocinergic and vasopressinergic neurons and cerebral cortex [116].
Localization (localized) of TRPV2 in neurons associated with cerebral cortex
6) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.76 Pain Relevance 0.40

General Comments

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