INT152720

Context Info Confidence 0.69 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 2.71 Pain Relevance 1.54

transport (Trpv2) plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2) cytoplasm (Trpv2)

Anatomy Link Frequency neurons 1 cerebral cortex 1 lamina 1 head 1 Trpv2 (Mus musculus)

Pain Link Frequency Relevance Heat TRP channel 18 96.64 cerebral cortex 8 95.32 Neuropeptide 4 92.88 neuropeptide release 4 82.40 Pain 368 81.12 qutenza 94 80.64 Dorsal column 8 70.92 Neuropathic pain 28 68.48 Thermal hyperalgesia 36 67.60 depression 4 67.36

Disease Link Frequency Relevance Heat Nociception 68 99.12 Asthma 5 84.16 Cough 13 83.84 Urticaria 4 82.88 INFLAMMATION 58 82.76 Pain 384 81.12 Coronary Heart Disease 4 80.60 Stress Incontinence 4 78.84 Neuropathic Pain 84 68.48 Anxiety Disorder 8 68.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our finding of the presence of TRPV1 and TRPV2 in the ORNs, as well as in nerve fibers in the lamina propria, suggests that these TRP channels play a vital part in chemosensation by OE.

Localization (presence) of TRPV2 in lamina associated with trp channel

1) Confidence 0.69 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.06 Pain Relevance 0.23

TRPV1 and TRPV2 were often co-localized with substance P, while the co-localization of substance P and TRPV3 was rare and TRPV4 was not co-localized with substance P.

Localization (co-localized) of TRPV2

2) Confidence 0.67 Published 2008 Journal Acta Otolaryngol. Section Body Doc Link 18568506 Disease Relevance 0.25 Pain Relevance 0

These regulatory mechanisms that induce membrane localization of TRPV2 seem to be important regulation mechanisms for TRPV2 activation.

Localization (localization) of TRPV2

3) Confidence 0.48 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.41 Pain Relevance 0.27

Translocation of TRPV2 from intracellular locations to plasma membrane required for its activation is regulated by insulin-like growth factor-I (IGF-I) [99]; A-kinase anchoring proteins (AKAP)/cAMP/protein kinase A (PKA) mediated phosphorylation [197]; G-protein coupled receptor ligands like neuropeptide head activator (HA) via phosphatidylinositol 3-kinase (PI3-K) andof the Ca2+/calmodulin-dependent kinase (CAMK) signaling [17].

Localization (Translocation) of TRPV2 in head associated with neuropeptide

4) Confidence 0.48 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.47 Pain Relevance 0.23

In the brain, TRPV2 is localized to hypothalamic paraventricular, suprachiasmatic, supraoptic nuclei, oxytocinergic and vasopressinergic neurons and cerebral cortex [116].

Localization (localized) of TRPV2 in cerebral cortex associated with cerebral cortex

5) Confidence 0.45 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.76 Pain Relevance 0.40

In the brain, TRPV2 is localized to hypothalamic paraventricular, suprachiasmatic, supraoptic nuclei, oxytocinergic and vasopressinergic neurons and cerebral cortex [116].

Localization (localized) of TRPV2 in neurons associated with cerebral cortex

6) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.76 Pain Relevance 0.40

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