INT152728

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.96
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a8) extracellular region (S100a8) plasma membrane (S100a8)
cytoskeleton (S100a8) cytoplasm (S100a8)
Anatomy Link Frequency
fibroblasts 3
neutrophil 2
T cells 1
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 53 100.00 Very High Very High Very High
cytokine 22 100.00 Very High Very High Very High
Inflammatory mediators 6 100.00 Very High Very High Very High
Multiple sclerosis 34 98.40 Very High Very High Very High
Opioid 4 75.00 Quite High
antagonist 3 75.00 Quite High
dexamethasone 44 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 61 100.00 Very High Very High Very High
Multiple Sclerosis 100 98.40 Very High Very High Very High
Weight Loss 2 95.92 Very High Very High Very High
Colitis 8 94.76 High High
Disease 30 94.08 High High
Chemotherapy-induced Neutropenia 1 91.44 High High
Apoptosis 74 88.88 High High
Corneal Neovascularization 6 85.24 High High
Inflammatory Bowel Disease 5 75.00 Quite High
Chemical Burns 6 74.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RT-QPCR analysis confirmed that neutrophil depletion in the mice significantly decreased, but did not completely abrogate the upregulation of the aforementioned genes (including S100A8, S100A9, IL-1?
Neg (not) Negative_regulation (abrogate) of Positive_regulation (upregulation) of S100A8 in neutrophil
1) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.50 Pain Relevance 0.12
Significantly, elevated levels of colonic RNA for pro-inflammatory cytokines interleukin (IL)-6 and IL-12 were also decreased toward normal with NTX.
Negative_regulation (decreased) of Positive_regulation (elevated) of pro-inflammatory associated with inflammation and cytokine
2) Confidence 0.12 Published 2008 Journal J Immunotoxicol Section Abstract Doc Link 18569389 Disease Relevance 1.75 Pain Relevance 0.79
CpdA inhibited pro-inflammatory mediators in myelin-specific T cells and fibroblasts in a GR-dependent manner while gene activation was abolished.
Negative_regulation (inhibited) of Positive_regulation (mediators) of pro-inflammatory in fibroblasts associated with inflammatory mediators
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781169 Disease Relevance 0.85 Pain Relevance 0.19
CpdA inhibited pro-inflammatory mediators in myelin-specific T cells and fibroblasts in a GR-dependent manner while gene activation was abolished.
Negative_regulation (inhibited) of in T cells Positive_regulation (mediators) of pro-inflammatory in fibroblasts associated with inflammatory mediators
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781169 Disease Relevance 0.85 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox