INT152729

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 33
Disease Relevance 32.25
Pain Relevance 13.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a8) extracellular region (S100a8) plasma membrane (S100a8)
cytoskeleton (S100a8) cytoplasm (S100a8)
Anatomy Link Frequency
neutrophil 8
macrophages 6
DA neurons 2
liver 2
dendritic cell 2
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1184 100.00 Very High Very High Very High
cytokine 405 100.00 Very High Very High Very High
chemokine 46 100.00 Very High Very High Very High
Inflammatory response 44 99.76 Very High Very High Very High
Arthritis 203 99.16 Very High Very High Very High
dexamethasone 24 98.50 Very High Very High Very High
Potency 11 95.68 Very High Very High Very High
Inflammatory mediators 46 93.16 High High
ischemia 25 92.56 High High
Pain 33 92.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1279 100.00 Very High Very High Very High
Chemotherapy-induced Neutropenia 1 100.00 Very High Very High Very High
Autoimmune Disease 13 99.92 Very High Very High Very High
Cancer 320 99.86 Very High Very High Very High
Colitis 33 99.46 Very High Very High Very High
Crystal Associated Disease 150 99.34 Very High Very High Very High
Obesity 147 99.28 Very High Very High Very High
Arthritis 204 99.16 Very High Very High Very High
Hyperalgesia 33 99.04 Very High Very High Very High
Necrosis 42 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further showed that depletion of neutrophils decreased S100A8 and S100A9 expression in S-CorNV corneas compared to control S-CorNV corneas (Figure 3).
Negative_regulation (decreased) of Gene_expression (expression) of S100A8 in corneas associated with chemotherapy-induced neutropenia
1) Confidence 0.42 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.49 Pain Relevance 0.11
The first possibility seems unlikely because expression levels of S100A8/A9 and IL-1F8 were similar in cultured keratinocytes from mice of both genotypes.
Negative_regulation (levels) of Gene_expression (expression) of S100A8 in keratinocytes
2) Confidence 0.34 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.59 Pain Relevance 0.25
Blocking S100A8 and S100A9 expression in the premetastatic stage could prevent this permissive niche from being formed and thus inhibit the migration of tumor cells.


Negative_regulation (Blocking) of Gene_expression (expression) of S100A8 associated with cancer
3) Confidence 0.22 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.69 Pain Relevance 0.13
The mechanism by which NTX acts to reverse colitis is related in part to the decreased expression of pro-inflammatory cytokines.
Negative_regulation (decreased) of Gene_expression (expression) of pro-inflammatory associated with colitis, inflammation and cytokine
4) Confidence 0.12 Published 2008 Journal J Immunotoxicol Section Abstract Doc Link 18569389 Disease Relevance 1.40 Pain Relevance 0.42
However, eAE efficiently reduced pro-inflammatory cytokine (TNF-?
Negative_regulation (reduced) of Gene_expression (cytokine) of pro-inflammatory associated with inflammation and cytokine
5) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2976071 Disease Relevance 0.50 Pain Relevance 0.48
at 3.26 and 3.73-fold) and suppressed the anti-inflammatory cytokine level 2.29 and 2.32-fold compared with the 60?
Negative_regulation (suppressed) of Gene_expression (level) of anti-inflammatory cytokine associated with inflammation and cytokine
6) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2976071 Disease Relevance 0.60 Pain Relevance 0.64
Rx treatment also reduced the expression of macrophage markers and pro-inflammatory cytokines in the adipose tissue, indicating an ameliorating effect on chronic inflammation in the db/db diabetic mice.
Negative_regulation (reduced) of Gene_expression (expression) of pro-inflammatory in adipose tissue associated with inflammation, diabetes mellitus, obesity and cytokine
7) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.95 Pain Relevance 0.29
Topical steroid cream decreased the RT-induced inflammatory response, causing a reduction in levels of the pro-inflammatory cytokines IL-1?
Negative_regulation (reduction) of Gene_expression (levels) of pro-inflammatory associated with inflammatory response, inflammation and cytokine
8) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2955039 Disease Relevance 1.02 Pain Relevance 0.66
Indeed, there is evidence that at low concentrations, NO has anti-inflammatory properties as it inhibits the expression of pro-inflammatory proteins (i.e.
Negative_regulation (inhibits) of Gene_expression (expression) of pro-inflammatory associated with inflammation
9) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.84 Pain Relevance 0.47
Our results suggest that near-complete blockade of necrosis in the GCL of animals treated with ATP-liposomes correlated with a significant decrease in pro-inflammatory gene expression.
Negative_regulation (decrease) of Gene_expression (expression) of pro-inflammatory associated with necrosis and inflammation
10) Confidence 0.03 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013064 Disease Relevance 1.63 Pain Relevance 0.50
To limit the deleterious consequences of prolonged action of pro-inflammatory cytokines, their release is followed by the release of anti-inflammatory cytokines, such as IL-4, IL-10, and IL-13, which inhibit the production and action of the pro-inflammatory cytokines and are anti-hyperalgesic [24].
Negative_regulation (inhibit) of Gene_expression (production) of pro-inflammatory associated with hyperalgesia, inflammation and cytokine
11) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 1.92 Pain Relevance 1.67
The effective fractions that inhibited pro-inflammatory cytokine production in macrophages was further extracted with various organic solvents (butanol and ethyl acetate) and their anti-inflammatory activities were further determined.
Negative_regulation (inhibited) of Gene_expression (production) of pro-inflammatory in macrophages associated with inflammation and cytokine
12) Confidence 0.02 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.70 Pain Relevance 0.27
In this study, Radix Astragali was fractionated and its constituents were repeatedly screened for their activities in inhibiting pro-inflammatory cytokine production and lipopolysaccharide (LPS)-induced activation of the NF-?
Negative_regulation (inhibiting) of Gene_expression (production) of pro-inflammatory associated with inflammation and cytokine
13) Confidence 0.02 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 1.11 Pain Relevance 0.26
CONCLUSION: In the liver, CGRP exerts anti-inflammatory properties, which are characterized by a reduced production of pro-inflammatory cytokines.


Negative_regulation (reduced) of Gene_expression (production) of pro-inflammatory in liver
14) Confidence 0.02 Published 2009 Journal J. Hepatol. Section Body Doc Link 19464067 Disease Relevance 0 Pain Relevance 0
In addition, HCT1026 fed mice exhibited significantly reduced mRNA levels of pro-inflammatory cytokines, caspase-1, and iNOS in blood cells, with reduced number of CNS-infiltrating T cells [66].
Negative_regulation (reduced) of Gene_expression (cytokines) of pro-inflammatory in T cells associated with inflammation and cytokine
15) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.96 Pain Relevance 0.18
Among the pro-inflammatory cytokines measured, IL-1?
Negative_regulation (measured) of Gene_expression (cytokines) of pro-inflammatory associated with inflammation and cytokine
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.81 Pain Relevance 0.63
Dexamethasone inhibits leukocyte migration into sites of inflammation, predominantly by inhibiting the synthesis of pro-inflammatory cytokines and chemokines [24].
Negative_regulation (inhibiting) of Gene_expression (synthesis) of pro-inflammatory in leukocyte associated with chemokine, inflammation, dexamethasone and cytokine
17) Confidence 0.02 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 1.00 Pain Relevance 0.73
These observations indicate that successful phagocytosis suppresses pro-inflammatory gene expression in macrophages leading to the concept that impaired efferocytosis in the diabetic wound may be responsible for defective resolution of inflammation.


Negative_regulation (suppresses) of Gene_expression (expression) of pro-inflammatory in macrophages associated with inflammation, diabetes mellitus and injury
18) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832020 Disease Relevance 2.00 Pain Relevance 0.39
Neither of the supplemented diets was able to reduce the expression of pro-inflammatory cytokines.
Negative_regulation (reduce) of Gene_expression (expression) of pro-inflammatory associated with inflammation and cytokine
19) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2907316 Disease Relevance 1.05 Pain Relevance 0.71
Tregs prevent pathogenic autoimmunity by suppressing proliferation and production of pro-inflammatory cytokines in effector immune cells, such as helper T-lymphocytes [30].
Negative_regulation (suppressing) of Gene_expression (production) of pro-inflammatory in helper T-lymphocytes associated with autoimmune disease, inflammation and cytokine
20) Confidence 0.01 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.76 Pain Relevance 0.15

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