INT152730
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
UTI resulted in a substantial increase of S100A8/A9 protein in bladder and kidney tissue of WT mice. | |||||||||||||||
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S100A8/A9 are found in granulocytes, monocytes and early differentiation stages of macrophages and can be induced in keratinocytes and epithelial cells under inflammatory conditions [9], [10]. | |||||||||||||||
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As discussed previously, both the genes for MRP8 and its binding partner MRP14 are upregulated by wound-edge keratinocytes. | |||||||||||||||
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Four hours after zymosan challenge, both S100A8 and S100A9 were significantly increased in the presence of lidocaine (Fig. 4A and Table 1). | |||||||||||||||
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The role of S100A8/A9 during a local infection of the urinary tract system caused by E. coli remains unknown.
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The previous study [39] and our data oppose a role for S100A8/A9 in antibacterial defense mechanism. | |||||||||||||||
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The RT-QPCR analysis confirmed that neutrophil depletion in the mice significantly decreased, but did not completely abrogate the upregulation of the aforementioned genes (including S100A8, S100A9, IL-1? | |||||||||||||||
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Microarray profiling revealed that S100A4, S100A6, S100A8, S100A9, and S100A13 were upregulated in both CorNV models, with S100A8 and S100A9 manifesting the most significant changes compared to the normal animals. | |||||||||||||||
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As shown in figure 1AB, S100A8/A9 level was higher in bladder and kidney homogenates from WT mice 24 and 48 hours after induction of UTI compared to sham mice. | |||||||||||||||
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As shown in figure 1AB, S100A8/A9 level was higher in bladder and kidney homogenates from WT mice 24 and 48 hours after induction of UTI compared to sham mice. | |||||||||||||||
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The extent of upregulation of other detected S100A genes and pro-inflammatory or pro-angiogenic genes was also decreased by neutrophil depletion. | |||||||||||||||
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We also found up-regulation of S100A8 and S100A9, which are expressed by activated keratinocytes in hyperproliferative epidermis of psoriatic patients and in epidermal skin cancers and which act as chemoattractants for inflammatory cells (Gebhardt et al., 2006). | |||||||||||||||
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Upregulation of S100A8 and S100A9 in premetastatic lung tissue provide a niche for migration of tumor cells [123]. | |||||||||||||||
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Also, isoflurane selectively reduced zymosan-stimulated pro-inflammatory cytokine levels (Fig. 7B and Tables 6 and 7), which contrasts the events in mice treated with zymosan and anesthetic dose of lidocaine (0.08%), that significantly reduced anti-inflammatory IL-13 (Fig. 5B). | |||||||||||||||
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Our data show that both S100A8 and S100A9 are induced in the D12-M.tuberculosis-infected lungs (Table 7). | |||||||||||||||
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S100A8/A9 are found in granulocytes, monocytes and early differentiation stages of macrophages and can be induced in keratinocytes and epithelial cells under inflammatory conditions [9], [10]. | |||||||||||||||
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UTI resulted in a substantial increase of S100A8/A9 protein in bladder and kidney tissue of WT mice. | |||||||||||||||
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High levels of S100A8/A9 were observed in bladder and kidney tissue during UTI. | |||||||||||||||
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These data are in line with our results demonstrating that during UTI, levels of S100A8/A9 increased in both bladder and kidney homogenates. | |||||||||||||||
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As shown in figure 1AB, S100A8/A9 level was higher in bladder and kidney homogenates from WT mice 24 and 48 hours after induction of UTI compared to sham mice. | |||||||||||||||
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