INT152742

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.44
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
sympathetic 2
primary sensory neurons 2
axilla 2
urine 2
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 171 100.00 Very High Very High Very High
Inflammation 79 99.90 Very High Very High Very High
c fibre 14 99.22 Very High Very High Very High
Pain 298 98.60 Very High Very High Very High
Osteoarthritis 95 98.56 Very High Very High Very High
bradykinin 17 94.20 High High
Arthritis 8 93.68 High High
nociceptor 57 93.24 High High
headache 4 92.28 High High
Calcitonin gene-related peptide 10 90.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 95 99.90 Very High Very High Very High
Osteoarthritis 10 98.56 Very High Very High Very High
Pain 356 96.72 Very High Very High Very High
Injury 22 96.48 Very High Very High Very High
Intraoperative Complications 2 96.16 Very High Very High Very High
Disease 50 95.92 Very High Very High Very High
Overactive Bladder 50 93.92 High High
Arthritis 10 93.68 High High
Cystitis 2 93.24 High High
Headache 8 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, perfusion of the inflamed axilla with citric acid significantly enhanced the release of both NGF and BDNF.
Positive_regulation (enhanced) of Localization (release) of NGF in axilla associated with nerve growth factor
1) Confidence 0.50 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18571954 Disease Relevance 0.27 Pain Relevance 0.56
Although it is unclear at the moment if TRPV1 excitation enhances NGF release from urothelium, this neurotrophin was shown to induce bladder overactivity in experimental animals [31] and was found in high amounts in the urine of OAB patients [32].
Positive_regulation (enhances) of Localization (release) of NGF in urine associated with nerve growth factor and overactive bladder
2) Confidence 0.48 Published 2007 Journal BMC Urol Section Body Doc Link PMC1903357 Disease Relevance 0.09 Pain Relevance 0.42
were shown to increase NGF synthesis and release [27].
Positive_regulation (increase) of Localization (release) of NGF associated with nerve growth factor
3) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.37 Pain Relevance 0.48
in the modulation of neurotrophin expression in the IVD comes from studies by Abe and colleagues, who demonstrated an increase in NGF gene expression and protein secretion after NP cells (cultured in monolayer) were treated with IL-1?
Positive_regulation (increase) of Localization (secretion) of NGF associated with nerve growth factor
4) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.35 Pain Relevance 0.42
NGF may play an important role in linking sympathetic and C-fibre innervation as sympathetic activation stimulates NGF secretion from vascular smooth muscle [76].
Positive_regulation (stimulates) of Localization (secretion) of NGF in sympathetic associated with c fibre and nerve growth factor
5) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.13 Pain Relevance 1.01
Increased expression and release of NGF have been demonstrated in several painful conditions in animal models (for example, UV injury, surgical injury) [146,147] and in human conditions, including arthritis, cystitis, prostitis and headache [148-150].
Positive_regulation (Increased) of Localization (release) of NGF associated with pain, nerve growth factor, injury, cystitis, headache, intraoperative complications and arthritis
6) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.08 Pain Relevance 1.11
An increase in TRPV1 expression occurs in primary sensory neurons after peripheral inflammation and requires retrograde transport of nerve growth factor (NGF).
Positive_regulation (requires) of Localization (transport) of NGF in primary sensory neurons associated with nerve growth factor and inflammation
7) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 1.01 Pain Relevance 1.02

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