INT152743

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.04
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
spinal 2
astrocytes 2
skin 2
axilla 2
hippocampus 2
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 39 100.00 Very High Very High Very High
bDMF 5 100.00 Very High Very High Very High
spinal dorsal horn 2 100.00 Very High Very High Very High
antidepressant 103 99.98 Very High Very High Very High
Pain 91 99.16 Very High Very High Very High
Peripheral sensitization 2 97.48 Very High Very High Very High
Hippocampus 14 95.20 Very High Very High Very High
depression 75 94.64 High High
Morphine 4 92.68 High High
Lasting pain 22 90.96 High High
Disease Link Frequency Relevance Heat
Cognitive Disorder 3 99.80 Very High Very High Very High
Nervous System Injury 13 99.68 Very High Very High Very High
Pain 121 99.00 Very High Very High Very High
Death 5 96.82 Very High Very High Very High
Frailty 50 96.12 Very High Very High Very High
Depression 143 94.64 High High
Nociception 9 94.60 High High
Neurodegenerative Disease 17 91.60 High High
Huntington's Chorea 1 88.00 High High
Hypersensitivity 2 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, perfusion of the inflamed axilla with citric acid significantly enhanced the release of both NGF and BDNF.
Positive_regulation (enhanced) of Localization (release) of BDNF in axilla associated with nerve growth factor
1) Confidence 0.56 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18571954 Disease Relevance 0.27 Pain Relevance 0.56
These data demonstrate enhanced level of neurotrophin release in inflamed human skin in vivo which might well contribute to peripheral sensitization.
Positive_regulation (enhanced) of Localization (release) of neurotrophin in skin associated with peripheral sensitization
2) Confidence 0.49 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18571954 Disease Relevance 0.25 Pain Relevance 0.47
Figure 3d shows the median value of BDNF mRNA normalized over GAPDH (1), ?
Positive_regulation (over) of Localization (value) of BDNF mRNA
3) Confidence 0.43 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0 Pain Relevance 0
A single-nucleotide polymorphism in the human BDNF gene, resulting in a valine to methionine substitution (Val66Met) in the prodomain, has been shown to lead to reduced activity-induced BDNF secretion and memory impairment [7].
Positive_regulation (induced) of Localization (secretion) of BDNF associated with cognitive disorder
4) Confidence 0.36 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.42 Pain Relevance 0.17
Key observations leading to and strengthening this theory are: (1) neurotrophic factors, especially BDNF and VEGF, are under-expressed in limbic structures implicated in depression (especially the hippocampus) and may contribute to their observed atrophy and increased sensitivity to death (Sapolsky, 2000; Duman and Monteggia, 2006); (2) HPA-axis dysfunction exacerbates this phenomenon, while effective antidepressant treatments counteract it by enhancing hippocampal BDNF mRNA expression through the cAMP-CREB cascade (Duman et al., 1997, 2000); and (3) ECT and MAOI antidepressants, considered to be the most effective at relieving depressive symptoms, were shown to most significantly increase BDNF and trkB (the BDNF receptor) mRNA expression in the hippocampus (Nibuya et al., 1995).


Positive_regulation (enhancing) of Localization (expression) of BDNF in hippocampus associated with antidepressant, depression, frailty, hippocampus and death
5) Confidence 0.36 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2901135 Disease Relevance 1.08 Pain Relevance 0.53
Release of BDNF in the spinal dorsal horn increases spinal excitability and pain sensitization via TrkB receptors.
Positive_regulation (increases) of Localization (Release) of BDNF in spinal associated with pain and spinal dorsal horn
6) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.38 Pain Relevance 1.46
Antidepressants stimulate the secretion of neurotrophic factors, such as brain derived neurotrophic factor (BDNF).38 Antidepressants also enhance the secretion of S100B by astrocytes via serotonergic systems.15,39-41 Interestingly, in this study, the increase in serum S100B levels in response to treatment with antidepressants was more prominent in nonresponders than in responders.
Positive_regulation (stimulate) of Localization (secretion) of BDNF in astrocytes associated with antidepressant and bdmf
7) Confidence 0.09 Published 2008 Journal Psychiatry Investigation Section Body Doc Link PMC2796025 Disease Relevance 0.64 Pain Relevance 0.55

General Comments

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