INT15275

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Context Info
Confidence 0.37
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 6.43
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
peripheral nerve 2
PNS 2
T cell 1
Pmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 54 100.00 Very High Very High Very High
Peripheral nervous system 6 100.00 Very High Very High Very High
Inflammation 7 89.32 High High
Multiple sclerosis 1 83.76 Quite High
Demyelination 8 75.00 Quite High
cytokine 4 56.88 Quite High
tolerance 4 50.32 Quite High
Central nervous system 1 49.84 Quite Low
Disease Link Frequency Relevance Heat
Immunization 10 100.00 Very High Very High Very High
Neuritis 2 100.00 Very High Very High Very High
Hypersensitivity 2 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 52 99.76 Very High Very High Very High
Syndrome 6 98.76 Very High Very High Very High
Demyelinating Disease 10 89.88 High High
INFLAMMATION 7 89.32 High High
Disease 12 87.24 High High
Recurrence 4 75.00 Quite High
Pressure And Volume Under Development 1 36.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies demonstrate that sensitization of rats with a single myelin antigen, P2 protein, is sufficient to induce the clinical, electrophysiological, and neuropathological features of EAN.
P2 protein Binding (sensitization) of associated with neuritis
1) Confidence 0.37 Published 1984 Journal Ann. Neurol. Section Abstract Doc Link 6084458 Disease Relevance 0.48 Pain Relevance 0.48
The P2 protein, a small, highly ordered basic protein of peripheral nerve myelin, is a potent inducer of allergic neuritis in rats when complexed with phospholipids such as phosphatidylserine.
P2 protein Binding (complexed) of in peripheral nerve associated with hypersensitivity and neuritis
2) Confidence 0.37 Published 1981 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6170341 Disease Relevance 0.42 Pain Relevance 0.17
The line LiP2/A is exquisitely specific for P2 protein, exhibiting no reactivity to bovine basic protein or to PPD.
P2 protein Binding (specific) of
3) Confidence 0.31 Published 1984 Journal J. Immunol. Section Abstract Doc Link 6206142 Disease Relevance 0.26 Pain Relevance 0.14
Experimental allergic neuritis (EAN) was induced in 2 groups of inbred Lewis rats by sensitization with P2 protein and peripheral nervous system (PNS) myelin, both purified from bovine intradural roots.
P2 protein Binding (sensitization) of in PNS associated with peripheral nervous system, experimental autoimmune neuritis and neuritis
4) Confidence 0.18 Published 1983 Journal J. Neurol. Sci. Section Abstract Doc Link 6199467 Disease Relevance 0.36 Pain Relevance 0.46
The present study evaluates the effect of oral tolerization with BPM or P2 protein on the development of actively induced EAN.
P2 protein Binding (tolerization) of associated with neuritis
5) Confidence 0.17 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9394785 Disease Relevance 1.22 Pain Relevance 0.74
The effectiveness of T cell vaccination was analyzed in experimental autoimmune neuritis (EAN) that can be induced by immunization with bovine P2 protein or a peptide representing the amino acids 53-78 of P2 (P2 53-78).
P2 protein Binding (immunization) of in T cell associated with experimental autoimmune neuritis, immunization and neuritis
6) Confidence 0.16 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1720130 Disease Relevance 0.58 Pain Relevance 0.40
Vaccinated animals were not protected from EAN induced by immunization with P2 protein in complete Freund's adjuvant (CFA).
P2 protein Binding (immunization) of associated with immunization and neuritis
7) Confidence 0.16 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1720130 Disease Relevance 0.66 Pain Relevance 0.48
Lewis rats were immunized with P2 protein and peptides CN1, CN2 and CN3.
P2 protein Binding (immunized) of
8) Confidence 0.15 Published 1983 Journal J. Neuroimmunol. Section Abstract Doc Link 6187769 Disease Relevance 0.16 Pain Relevance 0.07
Lewis rats immunized with P2 protein, a 14.5-kDa protein of the peripheral nerve myelin, develop experimental allergic neuritis, a paralytic disorder with clinical, histologic, and electrophysiologic features similar to those of human Guillain-Barré syndrome (GBS).
P2 protein Binding (immunized) of in peripheral nerve associated with syndrome, experimental autoimmune neuritis and neuritis
9) Confidence 0.10 Published 1997 Journal J. Infect. Dis. Section Abstract Doc Link 9396703 Disease Relevance 0.75 Pain Relevance 0.35
EAN induced in Lewis rats by inoculation with the PNS P2 protein peptide 57-81 and FCA was strongly suppressed by Rolipram administered twice daily intraperitoneally from day 9 post immunization (p.i.), i.e. after onset of clinical EAN.
PNS P2 protein Binding (inoculation) of in PNS associated with peripheral nervous system, immunization and neuritis
10) Confidence 0.05 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10670428 Disease Relevance 1.27 Pain Relevance 0.86
Porcine P2 myelin protein primary structure and bound fatty acids determined by mass spectrometry.
Porcine P2 myelin protein Binding (bound) of
11) Confidence 0.02 Published 2010 Journal Anal Bioanal Chem Section Title Doc Link 20512566 Disease Relevance 0.26 Pain Relevance 0.16

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