INT15276

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Context Info
Confidence 0.36
First Reported 1991
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.56
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
plasma 1
spinal cord 1
neurons 1
brainstem 1
trachea 1
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 26 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
c fibre 5 98.90 Very High Very High Very High
Neuropeptide 3 97.86 Very High Very High Very High
Spinal cord 2 97.84 Very High Very High Very High
medulla 3 97.24 Very High Very High Very High
qutenza 7 94.36 High High
Inflammation 3 92.60 High High
antagonist 10 90.00 High High
agonist 3 83.24 Quite High
Disease Link Frequency Relevance Heat
Injury 2 94.18 High High
INFLAMMATION 1 92.60 High High
Neuropathic Pain 2 75.00 Quite High
Ganglion Cysts 1 75.00 Quite High
Causalgia 1 73.92 Quite High
Nervous System Injury 1 68.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
PPT mRNA Binding (associated) of in neurons associated with injury
1) Confidence 0.36 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.36
It is further shown that galanin, a naturally occurring neuropeptide present in primary afferents, also inhibits C-fiber activation-evoked plasma extravasation, indicating an interaction between galanin and tachykinins in the peripheral terminals of primary afferents, possibly through both pre- and postsynaptic mechanisms.
tachykinin Binding (interaction) of in plasma associated with c fibre and neuropeptide
2) Confidence 0.36 Published 1991 Journal Neuroscience Section Abstract Doc Link 1720225 Disease Relevance 0.09 Pain Relevance 0.62
In the afternoon, the tachykinin/NK(1)R and the enkephalin/MOR transmissions interact to control cholinergic transmission.
tachykinin Binding (interact) of associated with enkephalin
3) Confidence 0.32 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17949415 Disease Relevance 0 Pain Relevance 0.67
They all interacted with tachykinin NK1 (rabbit jugular vein) and tachykinin NK2 (rabbit pulmonary artery) receptors with pA2 values of about 6.5-7.5 at the NK1 receptor and of 5.9-7.2 at the NK2 receptor, while being inactive at the tachykinin NK3 receptor (rat portal vein).
tachykinin NK1 Binding (interacted) of in pulmonary artery
4) Confidence 0.10 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7527343 Disease Relevance 0 Pain Relevance 0.10
Binding of [125I]-Bolton-Hunter substance P ([125I]-BHSP), [125I]-neurokinin A and [3H]-senktide to tachykinin NK(1), NK(2) and NK(3) receptors, respectively, was examined in caudal brainstem sections of 10-week-old rats pretreated as neonates (P2) with capsaicin (50 mg/kg, s.c.) or vehicle. [125I]-BHSP binding was localised to the nucleus of the solitary tract (NTS), hypoglossal nucleus and inferior olivary complex, whereas [125I]-neurokinin A and [3H]-senktide binding were confined to the NTS.
tachykinin NK Spec (examined) Binding (Binding) of in brainstem associated with medulla, qutenza and substance p
5) Confidence 0.08 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850591 Disease Relevance 0 Pain Relevance 0.45
We have recently identified a specific binding site for the tachykinin peptide substance P (SP) fragment SP(1-7) in the rat spinal cord.
tachykinin Binding (binding) of in spinal cord associated with spinal cord and substance p
6) Confidence 0.07 Published 2008 Journal Peptides Section Abstract Doc Link 18597894 Disease Relevance 0 Pain Relevance 0.72
In the present study the presumed mast cell-tachykinin interaction was studied in isolated trachea from Fisher 344 rats.
cell-tachykinin Binding (interaction) of in trachea
7) Confidence 0.06 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9424020 Disease Relevance 0 Pain Relevance 0.24

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