INT152771

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 14.95
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (TJP1) plasma membrane (TJP1) nucleus (TJP1)
cytoplasm (TJP1)
Anatomy Link Frequency
plasma 4
jejunum 2
brains 1
lamina 1
MDCK 1
TJP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 7 99.62 Very High Very High Very High
Inflammation 82 97.78 Very High Very High Very High
Central nervous system 94 93.60 High High
metalloproteinase 27 93.04 High High
ischemia 135 92.36 High High
opiate 3 89.56 High High
cytokine 44 87.92 High High
alcohol 8 87.84 High High
chemokine 38 83.84 Quite High
Inflammatory mediators 14 73.12 Quite High
Disease Link Frequency Relevance Heat
Acute Renal Failure 332 99.22 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 448 99.20 Very High Very High Very High
Burns 296 99.00 Very High Very High Very High
Adhesions 159 98.26 Very High Very High Very High
Viral Meningitis 72 98.24 Very High Very High Very High
INFLAMMATION 111 97.78 Very High Very High Very High
Infection 162 96.38 Very High Very High Very High
Proteinuria 132 94.80 High High
Sepsis 109 94.76 High High
Apoptosis 249 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effect of morphine and/or tat on the expression of TJ proteins ZO-1, JAM-2, Occludin and P-glycoprotein and the functional effects of TJ modulation in BMVEC.
Gene_expression (expression) of ZO-1 associated with morphine
1) Confidence 0.75 Published 2008 Journal J. Clin. Immunol. Section Abstract Doc Link 18574677 Disease Relevance 0.66 Pain Relevance 0.58
These changes were associated with significantly lower expression of ZO-1 mRNA in biopsies of IBS as compared to healthy subjects.
Gene_expression (expression) of ZO-1 mRNA
2) Confidence 0.26 Published 2009 Journal Gut Section Body Doc Link 18824556 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Our study shows that colonic soluble mediators are able to reproduce functional (permeability) and molecular (ZO-1 mRNA expression) alterations observed in IBS patients.
Gene_expression (expression) of ZO-1 mRNA
3) Confidence 0.26 Published 2009 Journal Gut Section Body Doc Link 18824556 Disease Relevance 0 Pain Relevance 0
ZO-1 was detected at the apical pole of the epithelial cells in both the control jejunum and the jejunum after an ischemic period of 30 minutes (data not shown).
Gene_expression (detected) of ZO-1 in jejunum
4) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561292 Disease Relevance 0.15 Pain Relevance 0.07
In the shortly reperfused jejunum a substantial loss of ZO-1 expression was shown in the sheets of shedded cells, which was accompanied by a decreased cytoplasmatic immunoreactivity of I-FABP.


Gene_expression (expression) of ZO-1 in jejunum
5) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561292 Disease Relevance 0.60 Pain Relevance 0.15
Expression of the ZO-1 protein at the cell membrane between adjacent cells is seen in Figure 2D (white arrows).
Gene_expression (Expression) of ZO-1 protein
6) Confidence 0.22 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0 Pain Relevance 0
The cells coating the lamina propria were immunopositive for I-FABP and ZO-1, indicating that the epithelial continuity contained viable enterocytes with intact tight junctions (Figure 2D).
Gene_expression (immunopositive) of ZO-1 in lamina
7) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561292 Disease Relevance 0.42 Pain Relevance 0.08
Burns septic ARF group plasma also induced a decreased expression of E-cadherin and pan-cytokeratin epithelial markers (data not shown) and of the tight junction protein ZO-1 (Figure 5G–I).


Gene_expression (expression) of ZO-1 in plasma associated with acute renal failure and burns
8) Confidence 0.17 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 2.07 Pain Relevance 0.03
After challenge of tubular cells with burns septic ARF group plasma, we observed a marked decrease of ZO-1 expression with a simultaneous alteration of TER.
Gene_expression (expression) of ZO-1 in plasma associated with acute renal failure and burns
9) Confidence 0.13 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.04 Pain Relevance 0.03
Moreover, plasma from septic burns patients induced an alteration of polarity in tubular cells, as well as reduced expression of the tight junction protein ZO-1 and of the endocytic receptor megalin.
Gene_expression (expression) of ZO-1 in plasma associated with burns
10) Confidence 0.13 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2447585 Disease Relevance 2.68 Pain Relevance 0.07
Plasma from septic burns patients also exerted an alteration of tubular cell polarity, a reduced expression of the tight junction protein ZO-1 and of the endocytic receptor megalin.
Gene_expression (expression) of ZO-1 in Plasma associated with burns
11) Confidence 0.13 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.60 Pain Relevance 0.12
Of note, HIV infection of macrophages increased their expression of the CCL2 receptor, CCR2, and CCL2 mediated transmigration of HIV-infected PBMC reduced tight junction proteins occludin, claudin-1 and ZO-1 expression in a BBB model in vitro [94].
Gene_expression (expression) of ZO-1 in PBMC associated with acquired immune deficiency syndrome or hiv infection and infection
12) Confidence 0.09 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.54 Pain Relevance 0.20
The proteins of the TJs include the junctional adhesion molecules (JAM) (JAM-1, JAM-2 and JAM-3), occludin, the claudins, and zonula occludin proteins (ZO-1 and ZO-2).
Gene_expression (proteins) of ZO-1 associated with adhesions
13) Confidence 0.07 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.16 Pain Relevance 0
Furthermore, the pro-inflammatory and IFN-inducible gene products released by HBMEC upon exposure to HIV-1 have been found to down-regulate the expression of tight junction proteins claudin-5, ZO-1, and ZO-2 [112].
Gene_expression (expression) of ZO-1 associated with inflammation and acquired immune deficiency syndrome or hiv infection
14) Confidence 0.07 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.74 Pain Relevance 0.11
As such Tat reduces the expression of occludin, ZO-1, and ZO-2 in the caveolar compartment of HBMECs.
Gene_expression (expression) of ZO-1
15) Confidence 0.07 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.12 Pain Relevance 0.29
In particular zonula occludens (ZO-1) expression is modified in brains of patients with HIV encephalitis [71,84], and loss of occludin and claudin-5 correlates with areas of monocytes infiltration [85].
Gene_expression (expression) of ZO-1 in brains associated with acquired immune deficiency syndrome or hiv infection and viral meningitis
16) Confidence 0.06 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.38 Pain Relevance 0.08
-catenin, afadin, vinculin and ZO-1 are present in all parts of intercalated discs irrespective of whether their ultrastructure resembles more closely typical desmosomes or adherens junctions (Borrmann et al. 2006; Franke et al. 2006).
Gene_expression (present) of ZO-1
17) Confidence 0.05 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
No differences were seen between SW1990 and si-SW1990 with regard to mRNA expression of E-Cadherin, Snail, ZO-1, ZO-2, MMPs and integrins, whereas mRNA expression levels of ?
Gene_expression (expression) of ZO-1
18) Confidence 0.04 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2893453 Disease Relevance 0.38 Pain Relevance 0.17
The vast majority of Wt L. monocytogenes (98% ± 1.5%) attach to polarized MDCK monolayers directly above ZO-1 staining, the site of the tight junctions (Figure 2C, 2D), and adhesion, like invasion, is concentrated at multicellular junction sites (Figure 2C, 2D).
Gene_expression (staining) of ZO-1 in MDCK associated with adhesions
19) Confidence 0.04 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1354196 Disease Relevance 0.33 Pain Relevance 0

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