INT152777

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Context Info
Confidence 0.79
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.60
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mgmt) nucleus (Mgmt) DNA binding (Mgmt)
Mgmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
vincristine 1 54.88 Quite High
palliative 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Antiemetics 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 42 95.76 Very High Very High Very High
Glioma 47 85.00 Quite High
Toxicity 16 65.20 Quite High
Malignant Neoplastic Disease 19 50.00 Quite Low
Disease 24 33.72 Quite Low
Anaplastic Astrocytoma 50 5.00 Very Low Very Low Very Low
Glioblastoma 42 5.00 Very Low Very Low Very Low
Recurrence 16 5.00 Very Low Very Low Very Low
Vomiting 9 5.00 Very Low Very Low Very Low
Brain Tumor 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of 16 evaluable cases, 14 (13 high grade tumors) showed O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation.
Phosphorylation (methylation) of O-6-methylguanine-DNA
1) Confidence 0.79 Published 2008 Journal Can J Neurol Sci Section Body Doc Link 18574933 Disease Relevance 0.07 Pain Relevance 0
Of 16 evaluable cases, 14 (13 high grade tumors) showed O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation.
Phosphorylation (methylation) of MGMT
2) Confidence 0.79 Published 2008 Journal Can J Neurol Sci Section Body Doc Link 18574933 Disease Relevance 0.06 Pain Relevance 0
MGMT methylation status
Phosphorylation (methylation) of MGMT
3) Confidence 0.12 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.47 Pain Relevance 0.03

General Comments

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