INT152809

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.95
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hk2) carbohydrate metabolic process (Hk2) kinase activity (Hk2)
Anatomy Link Frequency
skeletal muscle 2
muscle 1
HK-2 1
Hk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 6 97.04 Very High Very High Very High
agonist 6 97.04 Very High Very High Very High
ischemia 152 83.72 Quite High
imagery 24 70.60 Quite High
antagonist 1 64.24 Quite High
anesthesia 12 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Sciatic nerve 4 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 72 95.84 Very High Very High Very High
Body Weight 12 95.28 Very High Very High Very High
Death 56 94.68 High High
Cv Unclassified Under Development 148 83.72 Quite High
Renal Disease 6 83.04 Quite High
Apoptosis 5 70.76 Quite High
Necrosis 1 70.08 Quite High
Targeted Disruption 24 65.60 Quite High
Reperfusion Injury 28 50.00 Quite Low
Shock 4 12.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, diminishing HKII also affects muscle force production in male animals.
Negative_regulation (diminishing) of HKII in muscle
1) Confidence 0.57 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.76 Pain Relevance 0.18
Conversely, decreasing HKII in skeletal muscle of male, but not female mice, significantly (p?
Negative_regulation (decreasing) of HKII in skeletal muscle
2) Confidence 0.50 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.34 Pain Relevance 0
However, even in this model of mild irreversible cell damage, decreasing the amount of HKII resulted in a significant (p?
Negative_regulation (decreasing) of HKII
3) Confidence 0.42 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.21 Pain Relevance 0.07
The data suggest that diminished amount of HKII in skeletal muscle of male, but not female, animals is associated with increased sensitivity towards structural acute I/R injury.
Negative_regulation (diminished) of HKII in skeletal muscle associated with injury
4) Confidence 0.42 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.22 Pain Relevance 0.04
Iohexol caused a direct dose-dependent reduction of HK-2 and rat pulmonary microvascular endothelial cell viability, but alpha(2)-agonists failed to preserve the viability of both cell types.
Negative_regulation (reduction) of HK-2 in HK-2 associated with agonist
5) Confidence 0.21 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18579700 Disease Relevance 0.41 Pain Relevance 0.69

General Comments

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