INT15284

Context Info Confidence 0.47 First Reported 1986 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 21 Total Number 21 Disease Relevance 8.88 Pain Relevance 5.52

cell differentiation (Lgals3) extracellular region (Lgals3) mRNA processing (Lgals3) proteinaceous extracellular matrix (Lgals3) plasma membrane (Lgals3) nucleus (Lgals3)

Anatomy Link Frequency pollen 4 spinal cord 2 acinar cells 1 immune system 1 fibroblasts 1 Lgals3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Chronic pancreatitis 36 100.00 cINOD 3 99.80 Spinal cord 8 99.74 Inflammatory response 8 99.40 Inflammation 39 99.38 depression 84 99.00 fibrosis 8 98.40 Enkephalin 11 97.40 Neuropeptide 1 96.72 qutenza 5 95.32

Disease Link Frequency Relevance Heat Pancreatitis 36 100.00 Asthma 10 99.96 INFLAMMATION 49 99.60 Shock 4 99.40 Eczema 109 99.24 Depression 84 99.00 Hypersensitivity 65 98.74 Anxiety Disorder 109 98.70 Fibrosis 8 98.40 Nociception 2 98.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results showed that all immunomodulatory drugs applied in clinically relevant doses affect both the gene (LGALS3) and protein expression level of galectin-3.

Positive_regulation (level) of LGALS3

1) Confidence 0.47 Published 2006 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16458432 Disease Relevance 0.18 Pain Relevance 0.22

The results showed that all immunomodulatory drugs applied in clinically relevant doses affect both the gene (LGALS3) and protein expression level of galectin-3.

Positive_regulation (level) of galectin-3

2) Confidence 0.47 Published 2006 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16458432 Disease Relevance 0.18 Pain Relevance 0.22

Previous studies of these genes, including markers of toxic stress, apoptosis, growth regulation and repair, were consistent with documented toxicologic responses to CCl4, where expression of components of cytochrome P450 and other metabolic enzymes (Cyp2C, Cyp3A18, Cyp3A9, SCS and Fmo1) were found to decrease, whereas certain genes involved in the inflammatory response and signal transduction were increased (CD44 and Lgals3) [7].

Positive_regulation (increased) of Lgals3 associated with stress, inflammatory response and apoptosis

3) Confidence 0.46 Published 2003 Journal Genome Biol Section Body Doc Link PMC156588 Disease Relevance 0.35 Pain Relevance 0.05

Of the 15 inflammatory genes tested, 12 genes (C1-INH, CCR5, CD44, CHI3L1, HSPB1, JAK3, LGALS3, LGALS3BP, LAMA5, PEDF, STAT3, TIMP1) were reproducibly upregulated at 3 months (Figures 4 &5).

Positive_regulation (upregulated) of LGALS3 associated with inflammation

4) Confidence 0.41 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.33 Pain Relevance 0.12

In the preliminary studies, intranasal administration was not useful for elevating IgE in Fischer rats.

Positive_regulation (elevating) of IgE

5) Confidence 0.25 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.13 Pain Relevance 0

A substantial part of the psychodermatological literature has focused on atopic forms of eczema, and many of the above referred hypotheses concerning possible explanatory factors for the association between anxiety and depression, and eczema presuppose the involvement of atopy (elevated levels of IgE, in addition to "atopic symptoms" [16]) as a part of the aetiological chain underlying this association.

Positive_regulation (elevated) of IgE associated with asthma, depression, anxiety disorder and eczema

6) Confidence 0.22 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2876073 Disease Relevance 1.65 Pain Relevance 0.33

The possible participation of diesel exhaust inhalation during the fetal period in the elevation of IgE against pollen in postnatal life was investigated.

Positive_regulation (elevation) of IgE in pollen

7) Confidence 0.17 Published 2002 Journal BMC Pregnancy Childbirth Section Abstract Doc Link PMC101391 Disease Relevance 0 Pain Relevance 0

Elevation of IgE against Japanese pollen was detected in the rats exposed to total or filtered diesel exhaust from the 7th day of gestation until 3 days after birth (Total-C-C, Filtered-C-C).

Positive_regulation (Elevation) of IgE in pollen

8) Confidence 0.17 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.12 Pain Relevance 0

The second objective was to determine which substances – particulate matter or the gaseous phase present in diesel exhaust – are responsible for the elevation of IgE.

Positive_regulation (elevation) of IgE

9) Confidence 0.17 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.24 Pain Relevance 0

The present study provides the first evidence that inhalation of diesel exhaust during the differentiation periods of the immune system accelerated the elevation of immunoglobulin E (IgE) against Japanese cedar pollen.

Positive_regulation (elevation) of IgE in pollen

10) Confidence 0.17 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.13 Pain Relevance 0

Regarding which substances were more responsible for insufficient development of the immune system and elevation of IgE, filtered-exhaust that included the gaseous phase and ultra fine particles measuring less than 0.05 ?

Positive_regulation (elevation) of IgE in immune system

11) Confidence 0.17 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.45 Pain Relevance 0

Inhalation of diesel exhaust during differentiation of the immune system accelerated the elevation of IgE against pollen.

Positive_regulation (elevation) of IgE in pollen

12) Confidence 0.17 Published 2002 Journal BMC Pregnancy Childbirth Section Abstract Doc Link PMC101391 Disease Relevance 0.08 Pain Relevance 0

Northern blot analysis revealed a 4.5-fold increase of galectin-1 mRNA (p < 0.01) and a 3.8-fold increase of galectin-3 mRNA (p < 0.01) in CP samples compared with normal controls.

Positive_regulation (increase) of galectin-3 mRNA associated with chronic pancreatitis

13) Confidence 0.15 Published 2000 Journal Lab. Invest. Section Abstract Doc Link 10950114 Disease Relevance 0.67 Pain Relevance 0.59

Up-regulation of galectin-1 in fibroblasts and galectin-3 in ductular complexes suggests a role of these lectins in tissue remodeling in CP.

Positive_regulation (Up-regulation) of galectin-3 in fibroblasts associated with chronic pancreatitis

14) Confidence 0.15 Published 2000 Journal Lab. Invest. Section Abstract Doc Link 10950114 Disease Relevance 0.73 Pain Relevance 0.63

Mast cells are involved in allergic reactions where they release numerous vasoactive and other mediators in response to IgE and antigen.

Positive_regulation (response) of IgE in Mast cells associated with hypersensitivity

15) Confidence 0.12 Published 1991 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 1720423 Disease Relevance 0.10 Pain Relevance 0.18

CP samples exhibited moderate to intense galectin-1 mRNA signals in fibroblasts, whereas galectin-3 mRNA signals were intense in the cells of ductular complexes and weak in the degenerating acinar cells.

Positive_regulation (intense) of galectin-3 mRNA in acinar cells associated with chronic pancreatitis

16) Confidence 0.11 Published 2000 Journal Lab. Invest. Section Abstract Doc Link 10950114 Disease Relevance 0.82 Pain Relevance 0.70

The level of circulating IgE and precipitating anti-ovalbumin antibodies decreased in rats given 10 injections of enkephalins.

Positive_regulation (circulating) of IgE associated with enkephalin

17) Confidence 0.10 Published 1987 Journal Immunol. Lett. Section Abstract Doc Link 3623636 Disease Relevance 0.74 Pain Relevance 0.70

Some, such as galectin-1, may be employed as anti-inflammatory agents, while others, such as galectin-3, are evidently suitable targets for anti-inflammatory drugs.

Positive_regulation (targets) of galectin-3 associated with inflammation and cinod

18) Confidence 0.07 Published 2002 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 16353421 Disease Relevance 0.74 Pain Relevance 0.28

Ligation of dorsal roots resulted in disappearance of lectin reactivity in the spinal cord and caused accumulation of lectin-positive material proximal to the ligature, indicating somatofugal transport of galactose-containing glycoconjugates.

Positive_regulation (disappearance) of lectin in spinal cord associated with spinal cord

19) Confidence 0.07 Published 1986 Journal Brain Res. Section Abstract Doc Link 2425897 Disease Relevance 0.41 Pain Relevance 0.62

Galectin-1 and galectin-3 in chronic pancreatitis.

Positive_regulation (pancreatitis) of galectin-3 associated with chronic pancreatitis

20) Confidence 0.05 Published 2000 Journal Lab. Invest. Section Title Doc Link 10950114 Disease Relevance 0.67 Pain Relevance 0.57

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