INT152854

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
spinal cord 1
PRS (Homo sapiens)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 5 100.00 Very High Very High Very High
cerebral cortex 1 98.88 Very High Very High Very High
induced neuropathy 3 98.72 Very High Very High Very High
Spinal cord 5 96.48 Very High Very High Very High
Sciatic nerve 6 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 3 98.72 Very High Very High Very High
Drug Induced Neurotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For that, we investigated the changes of CaM, CaMKII, protein kinase C (PKC) and polymerization ratios (PRs) of NF-L, NF-M and NF-H in cerebral cortex (CC, including total cortex and some gray), spinal cord (SC) and sciatic nerve (SN) of rats treated with HD at a dosage of 1.75 or 3.50 mmol/kg for 8 weeks (five times per week).
PRs Spec (investigated) Regulation (changes) of PKC in spinal cord associated with kinase c, sciatic nerve, cerebral cortex and spinal cord
1) Confidence 0.01 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18582483 Disease Relevance 0.19 Pain Relevance 0.76

General Comments

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