INT152861

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 12.19
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a9) extracellular region (S100a9) plasma membrane (S100a9)
cytoskeleton (S100a9) nucleus (S100a9) cytoplasm (S100a9)
Anatomy Link Frequency
neutrophil 2
granulocytes 1
monocytes 1
endothelial cells 1
leukocytes 1
S100a9 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 6 99.76 Very High Very High Very High
Eae 12 98.08 Very High Very High Very High
Inflammation 482 96.72 Very High Very High Very High
cytokine 116 91.68 High High
Neuropathic pain 6 89.44 High High
Sciatic nerve 4 83.92 Quite High
Hyperalgesia 6 82.08 Quite High
allodynia 4 80.96 Quite High
Spontaneous pain 4 79.76 Quite High
Arthritis 25 74.80 Quite High
Disease Link Frequency Relevance Heat
Death 19 100.00 Very High Very High Very High
Injury 356 99.20 Very High Very High Very High
Mycobacterial Infection 435 98.72 Very High Very High Very High
Disease 108 98.32 Very High Very High Very High
Inflammatory Pain 2 98.08 Very High Very High Very High
INFLAMMATION 547 96.72 Very High Very High Very High
Alzheimer's Dementia 21 95.08 Very High Very High Very High
Aids-related Complex 71 94.40 High High
Neuropathic Pain 10 89.44 High High
Sprains And Strains 62 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, S100A8 and S100A9, either as is or in form of heterodimers [30-33], have been shown to promote death or permeability of vascular endothelial cells by binding to specific molecules on them [34,35].
S100A9 Binding (binding) of in endothelial cells associated with death
1) Confidence 0.37 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.42 Pain Relevance 0.12
, FOS, S100 calcium binding protein A9 [S100A9], etc.) other "later" gene interactions were surprising (Figures 4 and 5).
S100 calcium binding protein A9 Binding (interactions) of
2) Confidence 0.36 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.22 Pain Relevance 0.16
The synthetic peptide identical to the C-terminus of murine S100A9 protein (mS100A9p) has antinociceptive effect on different acute inflammatory pain models.
S100A9 protein Binding (terminus) of associated with eae and antinociceptive
3) Confidence 0.35 Published 2008 Journal Peptides Section Abstract Doc Link 18582512 Disease Relevance 0.92 Pain Relevance 0.79
The synthetic peptide identical to the C-terminus of murine S100A9 protein (mS100A9p) has antinociceptive effect on different acute inflammatory pain models.
mS100A9p Binding (terminus) of associated with eae and antinociceptive
4) Confidence 0.30 Published 2008 Journal Peptides Section Abstract Doc Link 18582512 Disease Relevance 0.93 Pain Relevance 0.80
The heterophilic binding partner of MRP8 is MRP14, which does not appear in the same cluster but rather is expressed within the early inflammation cluster (see later), since, in addition to keratinocyte expression, it is expressed at high levels by wound leukocytes.
MRP14 Binding (binding) of in leukocytes associated with inflammation and injury
5) Confidence 0.30 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.44 Pain Relevance 0.05
As discussed previously, both the genes for MRP8 and its binding partner MRP14 are upregulated by wound-edge keratinocytes.
MRP14 Binding (binding) of in keratinocytes associated with injury
6) Confidence 0.29 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.30 Pain Relevance 0.27
Murine peritoneal cells were collected, total RNA was isolated using TriZol reagent (GIBCO BRL, Grand Island, NY) and reverse-transcribed followed by polymerase chain reactions (PCR) using HotStar Master mix (Qiagen) (95°C for 15 min, then 35 cycles of 95°C for 30 sec, 55°C for 30 sec and 72°C for 60 sec) with specific primers for mouse S100A9 (sense: 5?
S100A9 Binding (primers) of
7) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0 Pain Relevance 0
In the presence of calcium, S100A8 and S100A9 form tetramers and bind directly to microtubules.
S100A9 Binding (bind) of
8) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.48 Pain Relevance 0.09
S100A8 and S100A9 interact with both type III intermediate filaments and keratin filaments for the purpose of wound repair.
S100A9 Binding (interact) of in filaments associated with injury
9) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.58 Pain Relevance 0.08
Importantly, S100A8, S100A9, and S100A8/A9 have each been shown to induce neutrophil chemotaxis [60], [61].
S100A9 Binding (induce) of in neutrophil
10) Confidence 0.13 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.55 Pain Relevance 0.16
S100A8 and S100A9 are small calcium-binding proteins that are expressed in tuberculosis patients [59] and produced by activated neutrophils and monocytes.
S100A9 Binding (binding) of in monocytes associated with mycobacterial infection
11) Confidence 0.13 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.67 Pain Relevance 0.07
The predominant role of the innate immune system in systemic onset disease is also underscored by the high expression and serum concentrations of the calcium-binding proteins S100A8, S100A9, and S100A12, which are specifically secreted during activation of neutrophilic granulocytes and monocytes47).
S100A9 Binding (binding) of in granulocytes associated with disease
12) Confidence 0.11 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 1.02 Pain Relevance 0.24
S100A8 and S100A9 are small calcium-binding proteins that are expressed in tuberculosis patients [59] and produced by activated neutrophils and monocytes.
S100A9 Binding (binding) of in neutrophils associated with mycobacterial infection
13) Confidence 0.04 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.67 Pain Relevance 0.07

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