INT152864

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) nucleus (S100b) cytoplasm (S100b)
Anatomy Link Frequency
astrocyte 2
S100b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 3 100.00 Very High Very High Very High
tetrodotoxin 9 99.80 Very High Very High Very High
sodium channel 3 99.34 Very High Very High Very High
fluoxetine 4 99.18 Very High Very High Very High
Calcium channel 3 97.66 Very High Very High Very High
Serotonin 4 95.84 Very High Very High Very High
Glutamate 3 94.72 High High
antidepressant 2 87.88 High High
Disease Link Frequency Relevance Heat
Depressive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither inhibition of nitric oxide (NO) synthase by L-NAME nor addition of the NO donors sodium nitroprussid (SNP) or hydroxylamine (HA) to the medium altered basal S100B release.
Neg (nor) Regulation (altered) of Localization (release) of S100B
1) Confidence 0.52 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.22
Moreover, individual inhibition of PKC, PLA(2) or PLC all failed to attenuate the S100B release determined under control condition or enhanced by either OGD or REO.
Neg (failed) Regulation (attenuate) of Localization (release) of S100B
2) Confidence 0.38 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.30
Blockade of calcium channels with verapamil, chelating the Ca(+2) ions with BAPTA or blockade of sodium channels with tetrodotoxin (TTX) did not alter OGD- and REO-induced S100B release.
Neg (not) Regulation (alter) of Localization (release) of S100B associated with tetrodotoxin, calcium channel and sodium channel
3) Confidence 0.26 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.41
Here, we measured S100B secretion directly in hippocampal astrocyte cultures and hippocampal slices exposed to fluoxetine and observed a significant increment of S100B release in the presence of this SSRI, apparently dependent on protein kinase A (PKA).
Regulation (dependent) of Localization (release) of S100B in astrocyte associated with ssri and fluoxetine
4) Confidence 0.26 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.73

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox