INT152865

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 7
Disease Relevance 0
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) nucleus (S100b) cytoplasm (S100b)
Anatomy Link Frequency
astrocyte 4
S100b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 8 99.84 Very High Very High Very High
tetrodotoxin 15 99.42 Very High Very High Very High
sSRI 6 99.00 Very High Very High Very High
sodium channel 5 98.96 Very High Very High Very High
Serotonin 8 98.16 Very High Very High Very High
Calcium channel 5 97.28 Very High Very High Very High
Glutamate 5 94.72 High High
antidepressant 4 88.40 High High
Disease Link Frequency Relevance Heat
Depressive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, calcium and sodium currents that are sensitive to verapamil and TTX, respectively, are unlikely to contribute to the enhanced S100B release observed under these conditions.
Positive_regulation (contribute) of Localization (release) of S100B associated with tetrodotoxin
1) Confidence 0.68 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.38
Incubation of rat cortical slices in a medium that was not containing oxygen and glucose (oxygen-glucose deprivation, OGD) caused a 200% increase in the release of S100B.
Positive_regulation (caused) of Localization (release) of S100B
2) Confidence 0.59 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0
Here, we measured S100B secretion directly in hippocampal astrocyte cultures and hippocampal slices exposed to fluoxetine and observed a significant increment of S100B release in the presence of this SSRI, apparently dependent on protein kinase A (PKA).
Positive_regulation (increment) of Localization (release) of S100B in astrocyte associated with ssri and fluoxetine
3) Confidence 0.49 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.71
Blockade of calcium channels with verapamil, chelating the Ca(+2) ions with BAPTA or blockade of sodium channels with tetrodotoxin (TTX) did not alter OGD- and REO-induced S100B release.
Neg (not) Positive_regulation (induced) of Localization (release) of S100B associated with tetrodotoxin, calcium channel and sodium channel
4) Confidence 0.46 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.41
Additionally, calcium and sodium currents that are sensitive to verapamil and TTX, respectively, are unlikely to contribute to the enhanced S100B release observed under these conditions.
Positive_regulation (enhanced) of Localization (release) of S100B associated with tetrodotoxin
5) Confidence 0.46 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.38
Secretion of S100B, an astrocyte-derived neurotrophic protein, is stimulated by fluoxetine via a mechanism independent of serotonin.
Positive_regulation (stimulated) of Localization (Secretion) of S100B in astrocyte associated with serotonin and fluoxetine
6) Confidence 0.45 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.65
Incubation of rat cortical slices in a medium that was not containing oxygen and glucose (oxygen-glucose deprivation, OGD) caused a 200% increase in the release of S100B.
Positive_regulation (increase) of Localization (release) of S100B
7) Confidence 0.40 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0

General Comments

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