INT152868

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tnf, Trpv1) cytosol (Trpv1) signal transduction (Tnf)
extracellular space (Tnf) extracellular region (Tnf) intracellular (Tnf)
Anatomy Link Frequency
neurons 2
Tnf (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 7 100.00 Very High Very High Very High
Inflammation 2 90.40 High High
Hyperalgesia 2 89.36 High High
Calcitonin gene-related peptide 1 88.56 High High
Pain 2 88.00 High High
cytokine 2 62.28 Quite High
Disease Link Frequency Relevance Heat
Cancer 2 75.00 Quite High
Necrosis 2 75.00 Quite High
Hyperalgesia 2 51.56 Quite High
Pain 2 50.88 Quite High
INFLAMMATION 2 49.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, our data demonstrate that TNFalpha directly enhances the sensitivity of rat trigeminal neurons to capsaicin via both rapid, non-genomic mechanisms as well as sustained genomic regulation in TRPV1 expression.
TNFalpha Regulation (regulation) of Gene_expression (expression) of TRPV1 in neurons associated with qutenza
1) Confidence 0.27 Published 2008 Journal Neuroscience Section Abstract Doc Link 18582539 Disease Relevance 0.25 Pain Relevance 0.86

General Comments

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