INT152885

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 7.62
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
macrophages 4
granulocytes 2
endothelial cells 1
B lymphocytes 1
plaques 1
Itgam (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 215 100.00 Very High Very High Very High
Inflammatory marker 3 97.72 Very High Very High Very High
Inflammation 173 93.76 High High
Potency 1 90.96 High High
chemokine 29 89.08 High High
ischemia 44 83.68 Quite High
Multiple sclerosis 4 82.00 Quite High
Spinal cord 2 80.92 Quite High
Pain 4 79.52 Quite High
fibrosis 8 78.20 Quite High
Disease Link Frequency Relevance Heat
Disease 79 99.84 Very High Very High Very High
Hypersensitivity 39 99.82 Very High Very High Very High
Obesity 64 99.38 Very High Very High Very High
Adhesions 15 98.80 Very High Very High Very High
INFLAMMATION 205 97.72 Very High Very High Very High
Targeted Disruption 57 96.84 Very High Very High Very High
Amyloid Plaque 13 96.16 Very High Very High Very High
Mycobacterial Infection 148 95.76 Very High Very High Very High
Insulin Resistance 38 95.12 Very High Very High Very High
Dental Caries 2 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to obtain purified spleen cell populations for the real-time RT-PCR experiments, after erythrocyte lysis, the splenocytes were appropriately stained with PE anti CD11b for the mieloyd line, PE-anti-CD3 antibody for T lymphocytes and FITC anti CD19 for B lymphocytes (Miltenyi Biotec, Bologna, Italy) and the CD11b+, CD3+ CD19+ populations were purified (purity ?
Localization (stained) of CD11b in B lymphocytes
1) Confidence 0.73 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.06
showed increased protein expression by CD11b+CD45dim microglia and infiltrating CD11b+CD45high macrophages/granulocytes after 24 hours of pMCAO (Figure 5E).
Localization (granulocytes) of CD11b in macrophages
2) Confidence 0.44 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.08 Pain Relevance 0
Figure 4d shows the result of the co-localization between the ProSense-680+ (red) and CD11b+ (green) fluorescent images.
Localization (localization) of CD11b
3) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.52 Pain Relevance 0
For analysis of microglia and macrophages/granulocytes, cells were gated on side scatter (SSC) versus CD11b, followed by forward scatter (FSC) versus CD11b, and FSC versus CD45.
Localization (followed) of CD11b in macrophages associated with hypersensitivity
4) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.15 Pain Relevance 0
LFA-1 has been shown to overshadow the contribution of CR3 for neutrophil migration and adhesion to endothelial cells, indicating that CR3 is not absolutely necessary (Ding et al., 1999).
Localization (contribution) of CR3 in endothelial cells associated with adhesions
5) Confidence 0.34 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.65 Pain Relevance 0.10
In adipose tissue from WT mice, HFD resulted in recruitment of CD11b+, F4/80+ macrophages and elevated protein levels of the inflammatory markers IL-1?
Localization (recruitment) of CD11b in macrophages associated with inflammatory marker and obesity
6) Confidence 0.29 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2746280 Disease Relevance 1.83 Pain Relevance 0.37
molecules and are thus defined as double negative DCs (CD11b?
Neg (negative) Localization (double) of CD11b
7) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0.05
These cells were distinct from the hematopoietic lineage as CD11b, CD14, and CD45 mRNA were not expressed.
Localization (lineage) of CD11b
8) Confidence 0.26 Published 2008 Journal Stem Cells Section Abstract Doc Link 18583536 Disease Relevance 0.31 Pain Relevance 0.16
The primary antibodies used were: rabbit anti-mouse GFAP (1: 1000, Sigma), rat anti-mouse Mac-1 (1: 250, Serotec, Oxford, United Kingdom), rabbit anti-human A?
Localization (anti) of Mac-1
9) Confidence 0.21 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 0.09 Pain Relevance 0.04
g/ml primary rat mAbs directed against mouse Mac-1 (macrophages and neutrophil granulocytes; Medac, Wedel, Germany) or Gr-1 (neutrophil granulocytes; BD Biosciences, Heidelberg, Germany) for 1 h at 22°C, followed by incubation with biotinylated secondary goat anti-rat IgG Abs (Dako, Glostrup, Denmark).
Localization (directed) of Mac-1 in macrophages
10) Confidence 0.16 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.45 Pain Relevance 0.14
showed increased protein expression by CD11b+CD45dim microglia and infiltrating CD11b+CD45high macrophages/granulocytes after 24 hours of pMCAO (Figure 5E).
Localization (granulocytes) of CD11b in granulocytes
11) Confidence 0.15 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.08 Pain Relevance 0
For this reason, we experimentally determined the timing of accumulation of Gr1+ neutrophilic population (CD11b+ Gr1+) (Figure 5a) [68] and Gr1+ monocytic population (CD11b?
Localization (population) of CD11b
12) Confidence 0.14 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.97 Pain Relevance 0.17
For analysis of microglia and macrophages/granulocytes, cells were gated on side scatter (SSC) versus CD11b, followed by forward scatter (FSC) versus CD11b, and FSC versus CD45.
Localization (followed) of CD11b in granulocytes associated with hypersensitivity
13) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.15 Pain Relevance 0
For analysis of microglia and macrophages/granulocytes, cells were gated on side scatter (SSC) versus CD11b, followed by forward scatter (FSC) versus CD11b, and FSC versus CD45.
Localization (followed) of CD11b in microglia associated with hypersensitivity
14) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.15 Pain Relevance 0
Among them, complement proteins, from the initial component C1q through the terminal cytotoxic C5b-C9, the complement receptors CR3 and CR4, and complement inhibitors, cytokines and interleukins (TNF-alpha, IL-1, IL-2, IL-6), and acute phase reactants (alpha1-antichymotrypsin and alpha2-macroglobulin) were exclusively localized in AD plaques.
Localization (localized) of CR3 in plaques associated with disease and cytokine
15) Confidence 0.08 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 1.75 Pain Relevance 0.21
g/ml primary rat mAbs directed against mouse Mac-1 (macrophages and neutrophil granulocytes; Medac, Wedel, Germany) or Gr-1 (neutrophil granulocytes; BD Biosciences, Heidelberg, Germany) for 1 h at 22°C, followed by incubation with biotinylated secondary goat anti-rat IgG Abs (Dako, Glostrup, Denmark).
Localization (directed) of Mac-1 in neutrophil
16) Confidence 0.05 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.45 Pain Relevance 0.14

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