INT15290

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Context Info
Confidence 0.52
First Reported 1985
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 7.56
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cela1) extracellular region (Cela1)
Anatomy Link Frequency
urine 2
plasma 1
fat 1
Cela1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 34 99.08 Very High Very High Very High
Inflammation 3 94.92 High High
Pain 4 87.32 High High
abdominal pain 4 82.48 Quite High
Pain score 2 77.12 Quite High
Lasting pain 1 65.44 Quite High
alcohol 1 36.40 Quite Low
nud 4 10.00 Low Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 19 99.84 Very High Very High Very High
Pancreatitis 82 99.52 Very High Very High Very High
INFLAMMATION 3 94.92 High High
Recurrence 4 87.68 High High
Abdominal Pain 4 82.48 Quite High
Pain 3 77.12 Quite High
Disease 3 75.00 Quite High
Carcinoma 2 75.00 Quite High
Cancer 1 64.56 Quite High
Cholangitis 2 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of elastase 1 were detected in 60.9% of pancreatic cancer and in 61.1% of chronic pancreatitis patients; low values were found in only two subjects with pancreatic disease.
Gene_expression (levels) of elastase 1 associated with pancreatitis, pancreatic cancer and chronic pancreatitis
1) Confidence 0.52 Published 1985 Journal Klin. Wochenschr. Section Abstract Doc Link 3849621 Disease Relevance 0.98 Pain Relevance 0.32
CONCLUSIONS: Fecal elastase1 levels correlated with fecal fat excretion and BMI.
Gene_expression (levels) of elastase1 in fat
2) Confidence 0.44 Published 2009 Journal Indian J Gastroenterol Section Body Doc Link 20177867 Disease Relevance 0.06 Pain Relevance 0
RESULTS: Low pancreatic stool elastase1 (<200 microg/g stool) was observed in two-thirds of chronic pancreatitis patients and correlated with ductal dilatation, pancreatic atrophy and calcification (p<0.05).
Gene_expression (pancreatic) of elastase1
3) Confidence 0.44 Published 2009 Journal Indian J Gastroenterol Section Body Doc Link 20177867 Disease Relevance 0.08 Pain Relevance 0
METHODS: Stool elastase1 levels were measured in 101 patients using polyclonal ELISA and acid steatocrit was measured in 86 chronic pancreatitis patients.
Gene_expression (levels) of elastase1
4) Confidence 0.44 Published 2009 Journal Indian J Gastroenterol Section Body Doc Link 20177867 Disease Relevance 0.09 Pain Relevance 0
While the majority of elastase 1 in serum was accounted for by high molecular forms, probably the expression of complexes with serum inhibitors, free circulating enzyme was present in all patients with high serum elastase 1.
Gene_expression (expression) of elastase 1
5) Confidence 0.43 Published 1989 Journal Enzyme Section Abstract Doc Link 2591350 Disease Relevance 0.70 Pain Relevance 0.20
Serum and urine elastase 1, its renal output and clearance and urinary gamma-glutamyltransferase and ribonuclease excretions were measured in 16 patients with pancreatic cancer, 23 with chronic pancreatitis and in 22 healthy controls in order to evaluate elastase 1 plasma-urine transfer in chronic pancreatic disease and to investigate any factors that might influence the clearance of this enzyme.
Gene_expression (transfer) of elastase 1 in urine associated with pancreatitis, pancreatic cancer and chronic pancreatitis
6) Confidence 0.38 Published 1989 Journal Enzyme Section Abstract Doc Link 2591350 Disease Relevance 0.60 Pain Relevance 0.17
There was a negative correlation between disease duration and fecal elastase 1 levels.
Gene_expression (levels) of elastase 1
7) Confidence 0.35 Published 2009 Journal Pancreas Section Body Doc Link 19287334 Disease Relevance 0.07 Pain Relevance 0
Patients with dyspepsia or those who use pancreatic enzyme preparations had significantly lower fecal elastase 1 levels than others.
Gene_expression (levels) of elastase 1
8) Confidence 0.35 Published 2009 Journal Pancreas Section Body Doc Link 19287334 Disease Relevance 0.06 Pain Relevance 0
[Clinical evaluation of serum elastase-1 levels in patients with acute pancreatitis].
Gene_expression (levels) of serum elastase-1 associated with pancreatitis
9) Confidence 0.34 Published 1991 Journal Vojnosanit Pregl Section Title Doc Link 1720594 Disease Relevance 0.34 Pain Relevance 0.08
Although the availability of different amounts of ultrafiltrable enzyme may play a role in influencing elastase 1 plasma-urine transfer, renal tubular damage appears to be the most important factor influencing the increase in the urinary output of elastase 1.
Gene_expression (transfer) of elastase 1 in plasma
10) Confidence 0.34 Published 1989 Journal Enzyme Section Abstract Doc Link 2591350 Disease Relevance 0.51 Pain Relevance 0.12
Recently an ELISA using specific antibodies to detect elastase-1 in serum has become available.
Gene_expression (detect) of elastase-1
11) Confidence 0.12 Published 1999 Journal Z Gastroenterol Section Abstract Doc Link 10494604 Disease Relevance 0.14 Pain Relevance 0.06
The aim of the present study was to compare the changes of serum levels of ELISA-elastase-1, lipase and amylase in acute pancreatic damage following ERCP.
Gene_expression (levels) of ELISA-elastase-1
12) Confidence 0.11 Published 1999 Journal Z Gastroenterol Section Abstract Doc Link 10494604 Disease Relevance 0.35 Pain Relevance 0.14
In order to investigate modifications of serum levels of elastase 1, immunoreactive trypsin, alpha 1-antitrypsin and alpha 2-macroglobulin in chronic pancreatic disease, and to speculate on the possible relationships among these parameters, the enzymes and inhibitors were assayed in the sera of 33 control subjects, 34 pancreatic cancer, 28 chronic pancreatitis and 36 extra-pancreatic diseases.
Gene_expression (levels) of elastase 1 associated with pancreatic cancer, pancreatitis and chronic pancreatitis
13) Confidence 0.10 Published 1986 Journal Enzyme Section Abstract Doc Link 2427333 Disease Relevance 0.63 Pain Relevance 0.15
An increase of elastase 1, alpha 1-antitrypsin and alpha 2-macroglobulin was detected in pancreatic cancer, chronic pancreatitis and extra-pancreatic diseases; no changes were found for serum immunoreactive trypsin.
Gene_expression (detected) of elastase 1 associated with pancreatitis, pancreatic cancer and chronic pancreatitis
14) Confidence 0.10 Published 1986 Journal Enzyme Section Abstract Doc Link 2427333 Disease Relevance 0.76 Pain Relevance 0.20
Serum levels of elastase-1 were measured in 174 patients with pancreatic diseases and in 131 controls and were compared with the circulating levels of trypsin, lipase and amylase and with clinical data.
Gene_expression (levels) of elastase-1 associated with pancreatitis
15) Confidence 0.09 Published 1987 Journal Int. J. Pancreatol. Section Abstract Doc Link 2447209 Disease Relevance 0.40 Pain Relevance 0.20
Markedly raised concentrations of elastase 1 were found in all twenty-nine patients with acute pancreatitis (amylase was elevated in all but three and pancreatic isoamylase in all but one).
Gene_expression (found) of elastase 1 associated with pancreatitis
16) Confidence 0.04 Published 1987 Journal Br J Surg Section Abstract Doc Link 2435358 Disease Relevance 0.55 Pain Relevance 0.20
On entry, low levels of elastase-1 were found in 11.7% of the patients, high levels in 41.1%; in contrast, high levels of trypsin and lipase were found in only a small number of patients (5.8 and 11.7%, respectively), whereas low levels were present in a substantial number (47.8 and 32.3% for trypsin and lipase, respectively).
Gene_expression (levels) of elastase-1
17) Confidence 0.04 Published 1991 Journal Int. J. Pancreatol. Section Abstract Doc Link 1724259 Disease Relevance 0.38 Pain Relevance 0.22
Serum levels of amylase, pancreatic isoamylase, lipase, trypsinogen, and elastase 1 were determined in 41 patients with pancreatic carcinoma and compared with those 71 patients with chronic pancreatitis and 17 patients with digestive non-pancreatic carcinoma, in an attempt to evaluate their relative values in the diagnosis of pancreatic cancer.
Spec (determined) Gene_expression (levels) of elastase 1 associated with pancreatic cancer and chronic pancreatitis
18) Confidence 0.03 Published 1989 Journal G Ital Oncol Section Abstract Doc Link 2468605 Disease Relevance 0.52 Pain Relevance 0.10
We compared the diagnostic sensitivities of serum amylase, lipase (assayed enzymatically and immunologically), trypsinogen and elastase-1, the 2-h-timed urine amylase excretion and the ratio of amylase and creatinine clearances in the recognition of acute pancreatitis.
Gene_expression (excretion) of elastase-1 in urine associated with pancreatitis
19) Confidence 0.02 Published 1990 Journal Clin. Chim. Acta Section Abstract Doc Link 2323064 Disease Relevance 0.34 Pain Relevance 0.08
In the 21 patients with severe pancreatic insufficiency, abnormally low serum concentrations of trypsinogen were found in 12 patients (57%), of lipase and elastase-1 in 6 (29%), of pancreatic isoamylase in 5 (24%), and of amylase in 3 (14%).
Gene_expression (found) of elastase-1
20) Confidence 0.02 Published 2000 Journal Dig Liver Dis Section Body Doc Link 10975774 Disease Relevance 0 Pain Relevance 0

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