INT152901

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.73
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TRPV1) aging (CALCA) intracellular (CALCA)
cell-cell signaling (CALCA) cytoplasm (CALCA) lipid metabolic process (TRPV1)
Anatomy Link Frequency
endothelial cells 4
sensory nerves 4
TRPV1 (Homo sapiens)
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 56 100.00 Very High Very High Very High
antagonist 8 98.12 Very High Very High Very High
qutenza 20 92.32 High High
Disease Link Frequency Relevance Heat
Fever 8 87.16 High High
Injury 4 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study tested whether TRPV1 modulates the release and synthesis of CGRP in endothelial cells, and evaluated the protective effect of endothelial cell-derived CGRP.
TRPV1 Spec (whether) Regulation (modulates) of Localization (release) of CGRP in endothelial cell associated with calcitonin gene-related peptide
1) Confidence 0.44 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.21 Pain Relevance 0.55
These results indicate that TRPV1 also regulates the expression and secretion of endothelial cell-derived CGRP, which affords protective effects on endothelial cells.
TRPV1 Regulation (regulates) of Localization (secretion) of CGRP in endothelial cells associated with calcitonin gene-related peptide
2) Confidence 0.30 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.23 Pain Relevance 0.82
Transient receptor potential vanilloid 1(TRPV1), which modulates the synthesis and release of CGRP in sensory nerves, is also present in endothelial cells.
TRPV1 Regulation (modulates) of Localization (release) of CGRP in sensory nerves associated with calcitonin gene-related peptide
3) Confidence 0.27 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.14 Pain Relevance 0.46
Transient receptor potential vanilloid 1(TRPV1), which modulates the synthesis and release of CGRP in sensory nerves, is also present in endothelial cells.
Transient receptor potential vanilloid 1 Regulation (modulates) of Localization (release) of CGRP in sensory nerves associated with calcitonin gene-related peptide
4) Confidence 0.23 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.14 Pain Relevance 0.46

General Comments

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