INT152902

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.99
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
plasma 4
trigeminal ganglion 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 84 100.00 Very High Very High Very High
trigeminal ganglion 13 98.18 Very High Very High Very High
transdermal 13 97.24 Very High Very High Very High
antagonist 13 94.72 High High
qutenza 11 94.72 High High
Inflammation 1 84.32 Quite High
Migraine 42 77.60 Quite High
headache 14 76.88 Quite High
medulla 2 44.92 Quite Low
Sumatriptan 10 36.64 Quite Low
Disease Link Frequency Relevance Heat
Fever 2 99.88 Very High Very High Very High
Ganglion Cysts 13 98.18 Very High Very High Very High
Injury 2 87.88 High High
Neurogenic Inflammation 1 84.32 Quite High
Hypertension 4 79.52 Quite High
Migraine Disorders 3 77.60 Quite High
Aging 4 74.52 Quite High
Headache 50 66.80 Quite High
Increased Venous Pressure Under Development 9 18.72 Low Low
Infection 1 17.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that the number of circulating senescent EPCs was significantly increased in hypertension concomitantly with the decreased plasma level of CGRP and the decreased CGRP mRNA expression in EPCs.
Positive_regulation (increased) of Transcription (expression) of CGRP in plasma
1) Confidence 0.66 Published 2010 Journal J. Hypertens. Section Body Doc Link 20375903 Disease Relevance 0.15 Pain Relevance 0
Activation of CGRP receptors in cultured trigeminal ganglion cells increased the cAMP levels, which in turn led to elevated CGRP promoter activity and increased CGRP mRNA levels.
Positive_regulation (increased) of Transcription (levels) of CGRP in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and calcitonin gene-related peptide
2) Confidence 0.65 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.41 Pain Relevance 1.08
The results showed that the number of circulating senescent EPCs was significantly increased in hypertension concomitantly with the decreased plasma level of CGRP and the decreased CGRP mRNA expression in EPCs.
Positive_regulation (increased) of Transcription (expression) of CGRP in plasma
3) Confidence 0.47 Published 2010 Journal J. Hypertens. Section Body Doc Link 20375903 Disease Relevance 0.15 Pain Relevance 0
Hyperthermia also increased the level of CGRP mRNA.
Positive_regulation (increased) of Transcription (level) of CGRP associated with fever and calcitonin gene-related peptide
4) Confidence 0.46 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.27 Pain Relevance 0.92
They found that applied bipolar DC current profiles could enhance the absorption of the insulin and calcitonin.
Positive_regulation (enhance) of Transcription (absorption) of calcitonin
5) Confidence 0.34 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2527667 Disease Relevance 0 Pain Relevance 0.08

General Comments

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