INT152919

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.69
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sds) lyase activity (Sds) cellular amino acid metabolic process (Sds)
cytoplasm (Sds)
Anatomy Link Frequency
neuronal 1
SDH 1
Sds (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 46 100.00 Very High Very High Very High
spinal dorsal horn 5 100.00 Very High Very High Very High
Serotonin 1 99.28 Very High Very High Very High
GABAergic 18 98.36 Very High Very High Very High
Spinal cord 1 75.00 Quite High
Neurotransmitter 16 74.80 Quite High
Glutamate 36 73.44 Quite High
Pain 1 55.84 Quite High
Enkephalin 1 25.00 Low Low
depression 4 10.92 Low Low
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 3 95.60 Very High Very High Very High
Neurological Disease 4 79.64 Quite High
Targeted Disruption 1 70.48 Quite High
Adhesions 4 63.32 Quite High
Pain 1 55.84 Quite High
Nociception 1 55.48 Quite High
Epilepsy 4 11.48 Low Low
Depression 4 10.92 Low Low
Anxiety Disorder 4 10.44 Low Low
Cognitive Disorder 8 9.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we identified a
novel secreted GABAB1 isoform containing the SDs and addressed
whether such soluble isoforms have the potential to block neuronal
GABAB receptor functions in a dominant-negative manner.
Localization (secreted) of SDs in neuronal
1) Confidence 0.42 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.05 Pain Relevance 0
In addition to the membrane-bound GABAB1a and GABAB1b
subunit isoforms, the GABAB1 gene produces several
secreted isoforms that all include the SDs
(14-16).

Localization (secreted) of SDs
2) Confidence 0.42 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.06 Pain Relevance 0
Here, we
describe GABAB1j, a secreted GABAB1 isoform comprising
the two SDs. 
Localization (secreted) of SDs
3) Confidence 0.42 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2576543 Disease Relevance 0.08 Pain Relevance 0.16
Secreted isoforms containing SDs were also described for other receptors and
shown to exert dominant-negative effects by scavenging the binding partners of
the membrane-bound receptor
(25,
26). 
Localization (Secreted) of SDs
4) Confidence 0.40 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.06 Pain Relevance 0
These observations indicate that 5-HT(3A) receptor co-localizes with GABA and ENK in the SDH, suggesting that serotonin may activate GABAergic and ENKergic neurons via 5-HT(3A) receptor subunit and therefore affect the release of GABA and ENK.
Localization (co-localizes) of SDH in SDH associated with gaba, gabaergic, spinal dorsal horn and serotonin
5) Confidence 0.35 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18586398 Disease Relevance 0.43 Pain Relevance 0.68

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox