INT152927

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 5.85
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
dendrites 1
stellate cells 1
fibroblasts 1
cortex 1
hippocampus 1
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 146 99.90 Very High Very High Very High
Ventral tegmentum 8 99.32 Very High Very High Very High
Hippocampus 26 99.24 Very High Very High Very High
GABAergic 63 98.84 Very High Very High Very High
fibrosis 2 95.64 Very High Very High Very High
fluoxetine 6 94.88 High High
Chronic pancreatitis 1 94.44 High High
gABA 130 93.24 High High
medulla 13 92.96 High High
Eae 1 91.52 High High
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Depression 6 99.60 Very High Very High Very High
Apoptosis 43 99.44 Very High Very High Very High
Stress 18 99.22 Very High Very High Very High
Retina Disease 4 97.72 Very High Very High Very High
Optic Nerve Injuries 34 96.56 Very High Very High Very High
Cardiovascular Disease 2 95.68 Very High Very High Very High
Fibrosis 2 95.64 Very High Very High Very High
Pancreatitis 1 94.44 High High
Pancreatic Cancer 1 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, blocking ERK2 activity in the VTA produces stress-resistant behavioral responses in these same assays and also blocks a chronic stress-induced reduction in sucrose preference.
Negative_regulation (blocking) of ERK2 associated with stress and ventral tegmentum
1) Confidence 0.41 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519540 Disease Relevance 0.84 Pain Relevance 0.37
The basal level of ERK1/2 phosphorylation (i.e. in the absence PGF2?
Negative_regulation (level) of ERK1/2
2) Confidence 0.41 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
These changes were accompanied by diminished superoxide levels, decrease in oxidatively modified proteins (-60.8%; p<0.05) and reduced p38-MAPK and ERK1/2 hyperactivation (-50.4% and -35.4%, respectively; p<0.05).
Negative_regulation (reduced) of p38-MAPK
3) Confidence 0.36 Published 2009 Journal Diabetes Metab. Res. Rev. Section Body Doc Link 19177471 Disease Relevance 0 Pain Relevance 0
Test agents used included Mev (kindly provided by Huikwang Corporation, Tainan, Taiwan), a specific ERK2 inhibitor [25], ERK activation inhibitor peptide II (Calbiochem, San Diego, CA, USA); a specific MEK1/2 inhibitor [26,27], U0126 (Calbiochem); or a specific MNK1/2 inhibitor [28,29], CGP57380 (Tocris, Ellisville, MO, USA).
Negative_regulation (inhibitor) of ERK2
4) Confidence 0.34 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.19 Pain Relevance 0.09
Furthermore, the decreased ability of learning and the reduction of phosphorylated ERK1/2 level of the MTBE-treated rats was partly reversed by bicuculline injected 30 min before the training.
Negative_regulation (reduction) of ERK1/2
5) Confidence 0.32 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19344668 Disease Relevance 0.38 Pain Relevance 0.44
The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex.
Negative_regulation (decreased) of P-ERK2 in cortex associated with stress, depression and hippocampus
6) Confidence 0.29 Published 2008 Journal Neurobiol. Dis. Section Abstract Doc Link 18586506 Disease Relevance 0.62 Pain Relevance 0.71
Heme oxygenase-1 inhibits the proliferation of pancreatic stellate cells by repression of the extracellular signal-regulated kinase1/2 pathway.
Negative_regulation (repression) of extracellular signal-regulated kinase1/2 in stellate cells associated with repression
7) Confidence 0.16 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 18784349 Disease Relevance 0.66 Pain Relevance 0.14
Survival and anti-apoptotic signals [51] such as XIAP, ERK2, SOS, c-Raf-1, and YY1 are downregulated.
Negative_regulation (downregulated) of ERK2 associated with apoptosis
8) Confidence 0.11 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.34 Pain Relevance 0.10
The presence of 5 mM GLA caused a significant decrease in both ERK1 (27 ± 7.7%) and ERK2 (31 ± 8.7%) protein expression (Figure 2C, 2E) and mRNA expression (data not shown).
Negative_regulation (decrease) of ERK2
9) Confidence 0.11 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.46 Pain Relevance 0
ERK1 and ERK2 mRNA and protein expression was significantly decreased.
Negative_regulation (decreased) of ERK2
10) Confidence 0.11 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.88 Pain Relevance 0
Finally, LMH pups showed delayed learning, in parallel to decreased pCREB, pERK1, and pERK2 expression in the hippocampus.
Negative_regulation (decreased) of pERK2 in hippocampus associated with hippocampus
11) Confidence 0.07 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2871377 Disease Relevance 0.07 Pain Relevance 0.12
Finally, specific blockade of calcium-calmodulin kinase II (CaMKII) and of extracellular signal-regulated kinase 1 and 2 (ERK1/2) also prevented the GABAergic effects on dendritic growth (Borodinsky et al., 2003), indicating the involvement of Ca2+ induced activation of various kinases during the differentiation of CGC dendrites (Borodinsky et al., 2003).
Negative_regulation (blockade) of extracellular signal-regulated kinase 1 and 2 in dendrites associated with gabaergic
12) Confidence 0.05 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0 Pain Relevance 0.38
These data demonstrated that, among IL-1-activated MAPK pathways, ATRA was inhibitory only on ERK1/2 in rat synovial fibroblasts.

6.

Negative_regulation (inhibitory) of ERK1/2 in fibroblasts associated with agonist
13) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.28
M PD-98059 (inhibitor of ERK1/2; Sigma-Aldrich) or incubated with 1 ?
Negative_regulation (inhibitor) of ERK1/2
14) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.03
1 in the presence of SB203580, a selective p38-MAPK inhibitor, the increase in Ank mRNA level was not affected (Figure 4b).
Negative_regulation (inhibitor) of p38-MAPK
15) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.07
These results demonstrate that lercanidipine can suppress the proliferation of VSMCs via inhibiting cellular ROS, Ras-MEK1/2-ERK1/2, and PI3K-Akt pathways, and suggesting that it may have therapeutic relevance in the prevention of human restenosis.
Negative_regulation (inhibiting) of 2-ERK1 associated with cardiovascular disease
16) Confidence 0.00 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 18973813 Disease Relevance 0.42 Pain Relevance 0

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