INT152939

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.09
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
synapse 2
Shank 1
neurons 1
spines 1
brain 1
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 84 98.20 Very High Very High Very High
Neuropeptide 1 98.00 Very High Very High Very High
Glutamate receptor 22 97.84 Very High Very High Very High
agonist 4 97.32 Very High Very High Very High
Hippocampus 18 96.16 Very High Very High Very High
amygdala 11 91.44 High High
opioid receptor 3 89.44 High High
Morphine 2 88.16 High High
long-term potentiation 47 87.72 High High
addiction 8 83.48 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 122 95.40 Very High Very High Very High
Neurodegenerative Disease 4 94.60 High High
Congenital Anomalies 10 89.12 High High
Alzheimer's Dementia 21 50.00 Quite Low
Schizophrenia 13 50.00 Quite Low
Anaerobic Bacterial Infections 1 42.68 Quite Low
Anxiety Disorder 46 33.60 Quite Low
Sprains And Strains 12 27.88 Quite Low
Hypertension 1 27.60 Quite Low
Repression 4 11.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we conclude that the engineering of the TAP tag into PSD-95 using the knockin strategy has not altered the synaptic physiological function of PSD-95.
Neg (not) Regulation (altered) of PSD-95
1) Confidence 0.60 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.15 Pain Relevance 0.13
The synapse-specific regulation of PSD-95 capture and retention provides a case study on how synaptic stability could be achieved with highly dynamic synaptic proteins.
Regulation (regulation) of PSD-95 in synapse
2) Confidence 0.60 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
However, several prominent structural molecules that bind to PSD-95 directly or indirectly, including GKAP, Shank, and CaMKII, are developmentally regulated [75–78].
Regulation (regulated) of PSD-95 in Shank
3) Confidence 0.44 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
The PSD-95-GFP signal intensity in individual spines fluctuated little over imaging sessions lasting 90 min ((G ?
Regulation (intensity) of PSD-95-GFP in spines associated with imagery
4) Confidence 0.38 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.16
Studies in cultured neurons suggest that the stability of PSD-95 at synapses can be modulated by synaptic activity [40–42,44].
Regulation (modulated) of PSD-95 in synapses
5) Confidence 0.26 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
A separate quantitative PCR analysis of genes in the last of these groups confirms the dysregulation of both orphan (Gpr88) and known (DrD1A, Adora2A, Cnr1, Grm5, Gpr6) G protein-coupled receptors, scaffolding (PSD95, Homer1) and signaling (Sgk, Cap1) proteins, and neuropeptides (CCK, galanin).
Regulation (dysregulation) of PSD95 associated with neuropeptide
6) Confidence 0.16 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18588537 Disease Relevance 0.18 Pain Relevance 0.75
The absence of Neto1 had no effect on the overall abundance of NR1, NR2A, NR2B, PSD-95, GluR2, VAMP2, or GABAAR1 proteins (Figure 6L) in whole brain extracts, or of NR1, NR2A, NR2B, or PSD-95 in crude synaptosomes (Figure 6M).
Neg (no) Regulation (effect) of PSD-95 in brain
7) Confidence 0.13 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.17 Pain Relevance 0.05
Spectrin, the major target of calpain, is, like PSD-95, also suggested to be related to the localization of glutamate receptors [30], If calpain is hyperactivated in our mice, higher spectrin degradation may allow overexpression of glutamate receptors, but this does not have to be the reason of enhanced spatial memory.
Regulation (target) of PSD-95 associated with glutamate receptor
8) Confidence 0.13 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.17 Pain Relevance 0.23
Our laboratory has shown that FMRP and PSD-95 mRNAs are rapidly translated in mouse primary cortical neurons in response to the type 1 mGluR agonist DHPG [22].
Regulation (translated) of PSD-95 in neurons associated with agonist
9) Confidence 0.09 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.41 Pain Relevance 0.08

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