INT152951

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.22
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (LEF1) cell adhesion (LEF1) nucleus (LEF1)
DNA binding (LEF1) transcription factor binding (LEF1) cytoplasm (LEF1)
Anatomy Link Frequency
Thyroid 1
fin 1
LEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 8 100.00 Very High Very High Very High
Paracetamol 12 99.44 Very High Very High Very High
imagery 10 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Chronic Lymphoid Leukemia 152 96.56 Very High Very High Very High
Familial Adenomatous Polyposis 109 96.28 Very High Very High Very High
Apoptosis 48 95.72 Very High Very High Very High
Chromosomal Instability 1 92.72 High High
Thyroid Neoplasm 13 87.68 High High
Intestinal Cancer 2 82.24 Quite High
Cancer 60 80.08 Quite High
Toxicity 8 79.12 Quite High
Disease 20 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin accumulates in the cytoplasm and binds to several transcription factors of the TCF/LEF, thereby altering the expression of various genes affecting proliferation, differentiation, migration and apoptosis of cells.13 In addition, APC stabilizes microtubules, leading to chromosomal stability.15,16 Inactivation of APC can lead to defective chromosome segregation and aberrant mitosis.17

FAP and Thyroid Carcinoma

Negative_regulation (factors) of LEF in Thyroid associated with thyroid neoplasm, chromosomal instability, familial adenomatous polyposis and apoptosis
1) Confidence 0.41 Published 2008 Journal Ann Surg Oncol Section Body Doc Link PMC2518080 Disease Relevance 2.03 Pain Relevance 0
Further, repression of Lef1 by miR-203 blocks fin regeneration, whereas loss of miR-203 results in excess Lef1 levels and fin overgrowth.


Negative_regulation (repression) of Lef1 in fin associated with repression
2) Confidence 0.18 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.26 Pain Relevance 0
Furthermore, LEF but not its active metabolite, A77-1726, was shown to be the main inhibitor.
Negative_regulation (inhibitor) of LEF associated with leflunomide
3) Confidence 0.15 Published 2008 Journal Toxicol. Lett. Section Abstract Doc Link 18588957 Disease Relevance 0.44 Pain Relevance 1.31
This result suggests that EA binding to LEF-1 may lead to destabilization of the LEF-1/?
Negative_regulation (destabilization) of LEF
4) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.06 Pain Relevance 0
As shown in Figure 3, EA decreased LEF-1, cyclin D1 and fibronectin mRNA expression in a concentration-dependent fashion in CLL cells.
Negative_regulation (decreased) of LEF associated with chronic lymphoid leukemia
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.44 Pain Relevance 0

General Comments

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