INT15296

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Context Info
Confidence 0.29
First Reported 1982
Last Reported 2010
Negated 4
Speculated 6
Reported most in Abstract
Documents 45
Total Number 52
Disease Relevance 10.66
Pain Relevance 29.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
Anatomy Link Frequency
spinal 6
neurons 5
cerebellum 4
spinal cord 2
pyramidal neurons 2
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 347 100.00 Very High Very High Very High
Glutamate 150 100.00 Very High Very High Very High
antagonist 94 100.00 Very High Very High Very High
gABA 84 100.00 Very High Very High Very High
opioid receptor 37 100.00 Very High Very High Very High
mu opioid receptor 7 100.00 Very High Very High Very High
GABA receptor 7 100.00 Very High Very High Very High
noradrenaline 6 100.00 Very High Very High Very High
Pain 138 99.98 Very High Very High Very High
Morphine 32 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 33 100.00 Very High Very High Very High
Hypoxia 12 100.00 Very High Very High Very High
Pain 134 99.98 Very High Very High Very High
Nociception 202 99.56 Very High Very High Very High
Fever 5 99.12 Very High Very High Very High
Reprotox - General 1 6 98.68 Very High Very High Very High
Autoimmune Disease 30 98.64 Very High Very High Very High
Targeted Disruption 285 98.36 Very High Very High Very High
Overactive Bladder 4 98.20 Very High Very High Very High
Ganglion Cysts 83 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ketamine, but not phencyclidine, selectively modulates cerebellar GABA(A) receptors containing alpha6 and delta subunits.
Regulation (modulates) of receptors associated with gaba and ketamine
1) Confidence 0.29 Published 2008 Journal J. Neurosci. Section Title Doc Link 18480294 Disease Relevance 0.27 Pain Relevance 0.64
Both noncompetitively inhibit NMDA receptors, yet there is little evidence that these drugs affect GABA(A) receptors, the primary target of most anesthetics. alpha6beta2/3delta receptors are subtypes of the GABA(A) receptor family and are abundantly expressed in granular neurons within the adult cerebellum.
Neg (little) Regulation (affect) of receptors in cerebellum associated with gaba and nmda receptor
2) Confidence 0.29 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18480294 Disease Relevance 0.27 Pain Relevance 0.64
These results indicate that: (as) the regional alterations in the affinity and distribution of GABA receptors may play a role in the induction, maintenance, and regression of morphine tolerance; (b) abrupt withdrawal and antagonist precipitated withdrawal affect the GABA system differently, (c) chronic morphine treatment appears to influence the GABA receptors in the cerebellum, a region generally known for its lack of opiate receptors.
Spec (appears) Regulation (influence) of receptors in cerebellum associated with gaba, antagonist, gaba receptor, tolerance, opiate, withdrawal and morphine
3) Confidence 0.22 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6288864 Disease Relevance 0 Pain Relevance 1.17
However, upon intracerebroventricular (i.c.v.) administration in Swiss Webster mice, heroin and 6MAM act on delta receptors while morphine acts on mu receptors.
Regulation (acts) of receptors associated with intracerebroventricular and morphine
4) Confidence 0.20 Published 2000 Journal J. Biomed. Sci. Section Abstract Doc Link 10810246 Disease Relevance 0 Pain Relevance 1.17
Comparatively, dizocilpine (MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine maleate]), a potent noncompetitive antagonist of NMDA receptors that is structurally unrelated to PCP, did not produce any effect on alpha6beta2delta receptors.
Regulation (effect) of receptors associated with nmda receptor and antagonist
5) Confidence 0.13 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18480294 Disease Relevance 0.24 Pain Relevance 0.82
Both noncompetitively inhibit NMDA receptors, yet there is little evidence that these drugs affect GABA(A) receptors, the primary target of most anesthetics. alpha6beta2/3delta receptors are subtypes of the GABA(A) receptor family and are abundantly expressed in granular neurons within the adult cerebellum.
Regulation (target) of receptors in cerebellum associated with gaba and nmda receptor
6) Confidence 0.13 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18480294 Disease Relevance 0.27 Pain Relevance 0.65
Here, using an oocyte expression system, we show that at anesthetically relevant concentrations, ketamine, but not PCP, modulates alpha6beta2delta and alpha6beta3delta receptors.
Regulation (modulates) of receptors in oocyte associated with ketamine
7) Confidence 0.13 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18480294 Disease Relevance 0.23 Pain Relevance 0.72
Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice.
Regulation (targeting) of receptors associated with cocaine
8) Confidence 0.10 Published 2001 Journal Eur. J. Pharmacol. Section Title Doc Link 11426838 Disease Relevance 0.07 Pain Relevance 0.47
In homozygous mice, a down-regulation of mu and delta receptors was observed in the striatal and pallidal areas.
Regulation (regulation) of receptors
9) Confidence 0.10 Published 2008 Journal Neuroscience Section Abstract Doc Link 18424009 Disease Relevance 0.09 Pain Relevance 0.53
On the contrary, an up-regulation of kappa receptors was found in the striatal and nigral regions and might be related to a change in dynorphin levels.
Regulation (regulation) of receptors associated with dynorphin
10) Confidence 0.10 Published 2008 Journal Neuroscience Section Abstract Doc Link 18424009 Disease Relevance 0.08 Pain Relevance 0.54
Neuroactive steroidal modulation of immobilization-stress and possible involvement of GABA-A and mitochondrial diazepam binding inhibitor (DBI) receptors (MDR) has been investigated in mice.
Regulation (modulation) of receptors associated with stress and gaba
11) Confidence 0.09 Published 1996 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8972548 Disease Relevance 0.42 Pain Relevance 0.31
The purposes were to show that pentobarbital administered intracerebroventricularly (i.c.v.) antagonized the antinociceptive action of morphine given intrathecally in the tail-flick test in mice, determine whether this antagonistic action involved spinal release of dynorphin A (Dyn A) and demonstrate whether the mechanism involved gamma-aminobutyric acid (GABA) receptors.
Spec (whether) Regulation (involved) of receptors in spinal associated with gaba, dynorphin, tail-flick, antinociceptive and morphine
12) Confidence 0.07 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8099619 Disease Relevance 0 Pain Relevance 1.01
Role of NK1 tachykinin receptors in thermonociception: effect of (+/-)-CP 96,345, a non-peptide substance P antagonist, on the hot plate test in mice.
Regulation (effect) of receptors associated with nociceptor, antagonist and substance p
13) Confidence 0.07 Published 1991 Journal Neurosci. Lett. Section Title Doc Link 1720881 Disease Relevance 0 Pain Relevance 0.84
Based on the ability of selective antagonists of dopamine (Sch 23390, D1; Sulpiride, D2), glutamate (CPP, competitive NMDA; dizocilpine, non-competitive NMDA; NBQX, AMPA) and GABA (bicuculline, GABA(A); Sch 50911, GABA(B)) receptors, to inhibit or enhance the response to nicotine, we conclude that nicotine alters striatal Met-Enk, in part, via glutamate NMDA and AMPA receptors.
Regulation (alters) of receptors associated with gaba, glutamate, dopamine, nicotine and antagonist
14) Confidence 0.07 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996137 Disease Relevance 0 Pain Relevance 0.92
However, non-NMDA receptors are not involved in i.c.v. administered beta-endorphin-, DPDPE-, and U50, 488H-induced antinociception at the supraspinal level.
Neg (not) Regulation (involved) of receptors associated with antinociception and nmda receptor
15) Confidence 0.06 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7746356 Disease Relevance 0 Pain Relevance 1.35
In the present study, to clarify the opioid receptor subtypes involved in the antinociceptive action of MG, we investigated the effects of selective antagonists for mu-, delta- and kappa- opioid receptors on antinociception caused by the intracerebroventricular (i.c.v.) injection of MG in the tail-pinch and hot-plate tests in mice.
Spec (investigated) Regulation (effects) of receptors in tail associated with antinociception, antagonist, opioid receptor, intracerebroventricular and antinociceptive
16) Confidence 0.06 Published 1998 Journal Life Sci. Section Abstract Doc Link 9585164 Disease Relevance 0 Pain Relevance 1.09
The present result suggests that beta-arrestin-2 may tonically down-regulate a selected population of mu-opioid receptors activated by endomorphin-1 or DAMGO in the mouse spinal cord.
Regulation (population) of receptors in spinal cord associated with mu opioid receptor and spinal cord
17) Confidence 0.04 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12850536 Disease Relevance 0 Pain Relevance 0.94
These results show that the mu-opioid system participates in the control of acute neuroinflammation, further reinforcing our earlier finding that the opioid system is involved in the pathogenesis of fever induced by bacterial LPS, and that mu-opioid receptors are the target for morphine-induced hyperthermia.
Regulation (target) of receptors associated with mu opioid receptor, fever, opioid and morphine
18) Confidence 0.04 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17898318 Disease Relevance 0.48 Pain Relevance 0.51
In addition, patch-clamp recordings of acutely dissociated CA1 hippocampal pyramidal neurons from (-/-) and (+/+) mice were undertaken to investigate the effects of barbiturates on kainate-activated AMPA receptors and GABA-activated GABA(A) receptors.
Spec (investigate) Regulation (effects) of receptors in pyramidal neurons
19) Confidence 0.03 Published 1999 Journal Anesthesiology Section Body Doc Link 10551584 Disease Relevance 0 Pain Relevance 0
In addition, patch-clamp recordings of acutely dissociated CA1 hippocampal pyramidal neurons from (-/-) and (+/+) mice were undertaken to investigate the effects of barbiturates on kainate-activated AMPA receptors and GABA-activated GABA(A) receptors.
Spec (investigate) Regulation (effects) of receptors in pyramidal neurons
20) Confidence 0.03 Published 1999 Journal Anesthesiology Section Body Doc Link 10551584 Disease Relevance 0 Pain Relevance 0

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