INT152961

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 10.01
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
cerebellum 4
glial cells 2
spinal cords 2
ependymal cells 2
pia mater 2
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 8 99.56 Very High Very High Very High
Neuropathic pain 18 97.88 Very High Very High Very High
Central nervous system 76 97.76 Very High Very High Very High
Inflammation 38 97.60 Very High Very High Very High
cva 14 95.44 Very High Very High Very High
Morphine 8 93.80 High High
cocaine 6 92.76 High High
Nucleus accumbens 2 89.80 High High
amygdala 2 89.04 High High
Ventral tegmentum 2 87.80 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 1 99.92 Very High Very High Very High
Disease 46 99.68 Very High Very High Very High
Autism 32 99.08 Very High Very High Very High
Stress 19 98.98 Very High Very High Very High
Neuropathic Pain 30 97.88 Very High Very High Very High
INFLAMMATION 52 97.60 Very High Very High Very High
Dementia 29 97.04 Very High Very High Very High
Neuromyelitis Optica 32 96.04 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 95.52 Very High Very High Very High
Cv General 3 Under Development 9 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, CMS procedure significantly increased the hippocampal AQP4 expression, which was reversed by 4-week fluoxetine treatment.
Negative_regulation (reversed) of Gene_expression (expression) of AQP4 associated with stress and fluoxetine
1) Confidence 0.59 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.23 Pain Relevance 0.72
In addition to GFAP, altered expression of AQP4 has been associated with this neurologic disease; in particular AQP4 expression was decreased in cerebellum of subjects with autism.
Negative_regulation (decreased) of Gene_expression (expression) of AQP4 in cerebellum associated with autism and disease
2) Confidence 0.53 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.81 Pain Relevance 0.03
Decreased AQP4 expression may mean that cell structure, cell volume and ionic homeostatis are compromised.
Negative_regulation (Decreased) of Gene_expression (expression) of AQP4
3) Confidence 0.53 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.73 Pain Relevance 0
This observation was confirmed by immunoblot analysis of AQP4 expression, revealing a significant decrease of the AQP4 expression level by 30% as compared to the controls (Fig. 2A,B).
Negative_regulation (decrease) of Gene_expression (expression) of AQP4
4) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.32 Pain Relevance 0
Altered expression of aquaporin 4, apolipoprotein D, and prostaglandin synthase is indicative of modified LH physiology.
Negative_regulation (Altered) of Gene_expression (expression) of aquaporin 4 associated with disorder of lipid metabolism
5) Confidence 0.41 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18591478 Disease Relevance 0.27 Pain Relevance 0.54
In a recent study, RNAi technology has been used to specifically suppress AQP4 expression in astrocytes primary cultures and so to elucidate its functional role in glial cells [65, 66].
Negative_regulation (suppress) of Gene_expression (expression) of AQP4 in glial cells
6) Confidence 0.40 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.74 Pain Relevance 0.05
In addition to GFAP, altered expression of AQP4 has been associated with this neurologic disease; in particular AQP4 expression was decreased in cerebellum of subjects with autism.
Negative_regulation (altered) of Gene_expression (expression) of AQP4 in cerebellum associated with autism and disease
7) Confidence 0.39 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.85 Pain Relevance 0.03
Nevertheless, additional studies are necessary to determine whether altered AQP4 expression represents a protective and/or maladaptive response to CNS inflammation.
Negative_regulation (altered) of Gene_expression (expression) of AQP4 associated with inflammation and central nervous system
8) Confidence 0.39 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.35 Pain Relevance 0.16
AQP4 is also expressed in ependymal cells, but is absent from neurons, oligodendrocytes, and microglia [32].
Negative_regulation (absent) of Neg (absent) Gene_expression (expressed) of AQP4 in ependymal cells
9) Confidence 0.37 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.52 Pain Relevance 0.65
A representative western blot shows low AQP4 expression in uninjured samples, and highly increased AQP4 protein levels in the CNP spinal cords, consistent with GFAP expression changes.
Negative_regulation (shows) of Gene_expression (expression) of AQP4 in spinal cords associated with neuropathic pain
10) Confidence 0.37 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.27 Pain Relevance 0.69
Interestingly, hyperosmotic treatment of cultured rat astrocytes by mannitol or sorbitol increases the expression of AQP4 and AQP9 mRNAs and proteins, which is suppressed by treatment with the p38 MAPK inhibitor SB203580 [34].
Negative_regulation (suppressed) of Gene_expression (expression) of AQP4 in astrocytes
11) Confidence 0.35 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
Identification of AQP4 T cell determinants
Negative_regulation (Identification) of Spec (determinants) Gene_expression (determinants) of AQP4 in T cell
12) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.78 Pain Relevance 0.06
The astroglial water channel aquaporin (AQP4) is essential for the maintenance of BBB integrity.52 Antibodies to AQP4 have a highly specific role in neuromyelitis optica (NMO) and characteristically bind to cerebral microvessels, pia mater and VRSs.53 Secretin is important for other aquaporin expression via vasopressin, secretin receptor-null mice for example have reduced renal expression of AQP2 and AQP4.54 Thus VIP impairment may influence water channel function.
Negative_regulation (reduced) of Gene_expression (expression) of AQP4 in pia mater associated with neuromyelitis optica
13) Confidence 0.21 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.07 Pain Relevance 0

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