INT152964

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.18
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
cerebellum 2
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 30 97.76 Very High Very High Very High
Inflammation 6 97.60 Very High Very High Very High
Spinal cord 42 96.64 Very High Very High Very High
Morphine 5 93.80 High High
allodynia 3 93.72 High High
Sciatica 1 89.20 High High
Physical dependence 2 86.24 High High
Neuropathic pain 8 82.84 Quite High
mu opioid receptor 6 82.60 Quite High
Pain 32 75.60 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 1 99.92 Very High Very High Very High
Infection 6 99.46 Very High Very High Very High
Autism 24 99.08 Very High Very High Very High
Disease 8 98.32 Very High Very High Very High
INFLAMMATION 6 97.60 Very High Very High Very High
Dementia 15 97.04 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 95.52 Very High Very High Very High
Neuropathic Pain 14 93.72 High High
Nerve Root Compression 1 89.20 High High
Epilepsy 15 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prenatal influence infection in mice results in a down-regulation of AQP4 expression in the offspring at birth [26] that persists at adolescence [24].
Regulation (regulation) of Gene_expression (expression) of AQP4 associated with infection
1) Confidence 0.56 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.80 Pain Relevance 0
Finally, they did not observe significant difference in AQP4 expression between any of the treatment groups.
Regulation (difference) of Gene_expression (expression) of AQP4
2) Confidence 0.39 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.91 Pain Relevance 0.61
Altered expression of aquaporin 4, apolipoprotein D, and prostaglandin synthase is indicative of modified LH physiology.
Regulation (Altered) of Gene_expression (expression) of aquaporin 4 associated with disorder of lipid metabolism
3) Confidence 0.26 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18591478 Disease Relevance 0.27 Pain Relevance 0.54
In addition to GFAP, altered expression of AQP4 has been associated with this neurologic disease; in particular AQP4 expression was decreased in cerebellum of subjects with autism.
Regulation (altered) of Gene_expression (expression) of AQP4 in cerebellum associated with autism and disease
4) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.85 Pain Relevance 0.03
Nevertheless, additional studies are necessary to determine whether altered AQP4 expression represents a protective and/or maladaptive response to CNS inflammation.
Regulation (altered) of Gene_expression (expression) of AQP4 associated with inflammation and central nervous system
5) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.35 Pain Relevance 0.16

General Comments

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