INT15299

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 37
Total Number 39
Disease Relevance 10.09
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL1RL1) extracellular space (IL1RL1) extracellular region (IL1RL1)
plasma membrane (IL1RL1) intracellular (IL1RL1)
Anatomy Link Frequency
upper 3
muscle 2
synaptic cleft 1
PSCs 1
pancreas 1
IL1RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 126 100.00 Very High Very High Very High
cytokine 25 100.00 Very High Very High Very High
Nicotine 3 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
Chronic pancreatitis 8 99.28 Very High Very High Very High
cINOD 2 98.64 Very High Very High Very High
substance P 1 97.36 Very High Very High Very High
Inflammation 42 97.00 Very High Very High Very High
imagery 39 87.12 High High
tetrodotoxin 4 87.04 High High
Disease Link Frequency Relevance Heat
Depression 126 100.00 Very High Very High Very High
Necrosis 6 99.42 Very High Very High Very High
Fibrosis 9 99.34 Very High Very High Very High
Pancreatitis 8 99.28 Very High Very High Very High
Cancer 29 99.24 Very High Very High Very High
Disease 75 98.32 Very High Very High Very High
INFLAMMATION 49 98.24 Very High Very High Very High
Foreign Bodies 98 96.96 Very High Very High Very High
Sickle Cell Anemia 7 96.28 Very High Very High Very High
Hemolysis 1 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Messenger RNA expression for IL33, ST2L and IL1RAcP was analysed by northern blotting and real-time PCR analyses, and protein expression was assessed by western blotting and ELISA.
Spec (analysed) Gene_expression (expression) of ST2L
1) Confidence 0.69 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.09 Pain Relevance 0
RESULTS: IL33, ST2L and IL1RAcP were expressed by alpha-SMA-positive myofibroblasts in the fibrosis of chronic pancreatitis.
Gene_expression (expressed) of ST2L
2) Confidence 0.69 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.08 Pain Relevance 0
Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.
Gene_expression (Expression) of ST2L associated with cytokine
3) Confidence 0.69 Published 2010 Journal Gut Section Title Doc Link 19996325 Disease Relevance 0.09 Pain Relevance 0.24
ST2L mRNA was weakly detected in unstimulated cells, and IL4 and interferon gamma (IFNgamma) strongly enhanced ST2L expression via STAT6 and STAT1 signalling, respectively.
Gene_expression (expression) of ST2L
4) Confidence 0.69 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.06 Pain Relevance 0
To define the role of IL33 in fibrogenesis of the pancreas, the expression of IL33, ST2L and IL1RAcP was examined in chronic pancreatitis tissues.
Spec (examined) Gene_expression (expression) of ST2L in pancreas associated with fibrosis and chronic pancreatitis
5) Confidence 0.69 Published 2010 Journal Gut Section Abstract Doc Link 19996325 Disease Relevance 0.20 Pain Relevance 0.18
The expression of IL33, ST2L and IL1RAcP was evaluated by standard immunohistochemical procedures.
Gene_expression (expression) of ST2L
6) Confidence 0.69 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.09 Pain Relevance 0
Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.
Gene_expression (Expression) of interleukin 1-like associated with cytokine
7) Confidence 0.69 Published 2010 Journal Gut Section Title Doc Link 19996325 Disease Relevance 0.09 Pain Relevance 0.23
The current therapeutic model encourages a step-up approach that safely incorporates several currently available classes of agents: non-steroidal anti-inflammatory drugs, selective cyclo-oxygenase-2 inhibitors, glucocorticoids, disease-modifying anti-rheumatic drugs, and biological agents (tumour necrosis factor-alpha inhibitors and interleukin-1 receptor antagonist).
Gene_expression (antagonist) of interleukin-1 receptor associated with necrosis, inflammation, cancer, antagonist, cinod and disease
8) Confidence 0.63 Published 2003 Journal Best Pract Res Clin Rheumatol Section Abstract Doc Link 12915159 Disease Relevance 1.13 Pain Relevance 0.48
Kita, unpublished data) and via expression of IL1RL1 directly by eosinophils and indirectly by basophils, mast cells, dendritic cells, and Th2 cells [29], [30], [31].
Gene_expression (expression) of IL1RL1 in eosinophils
9) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.99 Pain Relevance 0.13
g·kg-1 produced T4/T1 = 0.4.
Gene_expression (produced) of T1
10) Confidence 0.34 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.13 Pain Relevance 0.07
We have also found that, during the onset and at similar T1, larger doses of vecuronium produce less fade than smaller doses (Figure 2).
Gene_expression (produce) of T1
11) Confidence 0.34 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.26 Pain Relevance 0.13
The twitches, be it T1 or T4, were calculated identically using the calculated peak value of [ARA] after the first or the fourth stimulus:
Gene_expression (be) of T1
12) Confidence 0.34 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0 Pain Relevance 0
The slower development of the decrease in [A]4/[A]1 relative to the development of T1 depression (Figure 4) also explains the phenomenon that larger doses of neuromuscular blocking drugs produce less fade (during the onset of NMB) as compared with smaller doses.
Gene_expression (depression) of T1 associated with depression
13) Confidence 0.34 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.10 Pain Relevance 0.05
When compared at identical values of T1, the T4/T1 ratios during the offset of NMB (lower panel in Figure 2) were lower than those observed during the onset.
Gene_expression (ratios) of T1
14) Confidence 0.34 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.12 Pain Relevance 0.06
The T4/T1 ratios as a function of T1 for various doses of vecuronium during the onset of NMB are presented in the upper panel of Figure 2.
Gene_expression (function) of T1 in upper
15) Confidence 0.34 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.17 Pain Relevance 0.08
The recorded strengths of T1 and T4 were expressed as fractions of T1 before the administration of vecuronium.
Gene_expression (expressed) of T1
16) Confidence 0.34 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.10 Pain Relevance 0.24
The T4/T1 ratios as a function of T1 for various doses of vecuronium during the onset of NMB are presented in the upper panel of Figure 2.
Gene_expression (presented) of T1 in upper
17) Confidence 0.34 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.17 Pain Relevance 0.08
The T4/T1 ratios as a function of T1 for various doses of vecuronium during the onset of NMB are presented in the upper panel of Figure 2.
Gene_expression (function) of T1 in upper
18) Confidence 0.34 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.16 Pain Relevance 0.08
The central area of the reactive lesion is observed as low intensities on T1- and high intensities on T2-weighted images with no enhancement, which suggests that the lesion is myxomatous or cystic (8,9).
Gene_expression (intensities) of T1 in central area
19) Confidence 0.33 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852748 Disease Relevance 1.15 Pain Relevance 0.19
In the third patient, a target appearance was clearly visible on both T1- and T2-weighted images, and we could strongly consider the existence of a foreign body.
Gene_expression (visible) of T1 in body associated with foreign bodies
20) Confidence 0.33 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852748 Disease Relevance 1.16 Pain Relevance 0.22

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