INT1530

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1975
Last Reported 2010
Negated 49
Speculated 30
Reported most in Abstract
Documents 382
Total Number 411
Disease Relevance 115.96
Pain Relevance 112.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
plasma 41
pituitary 12
blood 11
anterior pituitary 5
thyroid 4
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 1293 100.00 Very High Very High Very High
Clonidine 668 100.00 Very High Very High Very High
agonist 341 100.00 Very High Very High Very High
narcan 227 100.00 Very High Very High Very High
antagonist 188 100.00 Very High Very High Very High
Sumatriptan 106 100.00 Very High Very High Very High
Pain 101 100.00 Very High Very High Very High
Morphine 91 100.00 Very High Very High Very High
rheumatoid arthritis 82 100.00 Very High Very High Very High
Opioid 79 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acromegaly 1352 100.00 Very High Very High Very High
Disease 575 100.00 Very High Very High Very High
Stress 94 100.00 Very High Very High Very High
Headache 89 100.00 Very High Very High Very High
Rheumatoid Arthritis 85 100.00 Very High Very High Very High
Injury 16 100.00 Very High Very High Very High
Cancer Pain 2 100.00 Very High Very High Very High
Depression 106 99.98 Very High Very High Very High
Obesity 313 99.84 Very High Very High Very High
Hypertension 57 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GH dysregulation may only be evident in these patients in activation paradigms and has been most consistently demonstrated by challenges with the alpha(2)-noradrenergic agonist, clonidine.


Regulation (dysregulation) of GH
1) Confidence 0.61 Published 2005 Journal Psychoneuroendocrinology Section Body Doc Link 15358444 Disease Relevance 0 Pain Relevance 0
Clinically, however, bromocriptine was more effective than judged by the changes of GH levels.
Regulation (changes) of GH
2) Confidence 0.61 Published 1980 Journal Horm. Res. Section Abstract Doc Link 7390405 Disease Relevance 0.70 Pain Relevance 0.13
The lack of correlation between T and GH response in EHT suggests a neuroendocrine disturbance in modulation by T of the GH response to central alpha 2 adrenergic stimulation.
Regulation (response) of GH associated with hypertension
3) Confidence 0.61 Published 1989 Journal Clin Exp Hypertens A Section Abstract Doc Link 2612023 Disease Relevance 0.43 Pain Relevance 0.25
CONCLUSIONS: With use of pure depression and anxiety groups and careful control of other factors known to affect GH, these results demonstrate central nervous system noradrenergic dysfunction in anxiety disorders.
Regulation (affect) of GH in central nervous system
4) Confidence 0.58 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15576065 Disease Relevance 0 Pain Relevance 0
Other factors known to affect GH (weight, menstrual status, prior antidepressant, or other drug exposure) were controlled.
Regulation (affect) of GH
5) Confidence 0.58 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15576065 Disease Relevance 0 Pain Relevance 0
Placebo administration did not change plasma GH levels in any subject.
Neg (not) Regulation (change) of GH in plasma
6) Confidence 0.57 Published 1997 Journal Neuropsychobiology Section Abstract Doc Link 9097298 Disease Relevance 0.63 Pain Relevance 0.39
The investigators could not demonstrate differences between octreotide and lanreotide, ie, the effects on GH, IGF-I, and insulin were all similar (Baldelli et al 2003).
Regulation (effects) of GH
7) Confidence 0.55 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.45 Pain Relevance 0.07
Finally, in a study of 93 patients with acromegaly control of GH and IGF-I had a positive impact on the subscale appearance, but overall QoL was severely impaired (Matta et al 2008).


Regulation (control) of GH associated with acromegaly
8) Confidence 0.55 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.38 Pain Relevance 0.10
We conclude that pubertal age patients with Turner's syndrome secrete GH normally and do not have any abnormality in GH regulation.
Regulation (regulation) of GH associated with syndrome
9) Confidence 0.53 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2394779 Disease Relevance 0.42 Pain Relevance 0.07
Administration of placebo did not change plasma GH levels in any subject.
Neg (not) Regulation (change) of GH in plasma
10) Confidence 0.53 Published 1997 Journal Alcohol Alcohol. Section Abstract Doc Link 9131896 Disease Relevance 0 Pain Relevance 0.55
Age-related changes in gonadotropin, prolactin and growth hormone levels with reference to the development of uterine adenomyosis in female SHN mice.
Regulation (changes) of growth hormone in uterine associated with dismenorea
11) Confidence 0.51 Published 1993 Journal In Vivo Section Title Doc Link 8364165 Disease Relevance 0.50 Pain Relevance 0.39
The overall GH control increased from 46% to 54% (Lucas et al 2006).
Regulation (control) of GH
12) Confidence 0.48 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.13 Pain Relevance 0
Lanreotide AutogelĀ® controls GH in 58% and IGF-I in 48% of patients.
Regulation (controls) of GH
13) Confidence 0.48 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.06 Pain Relevance 0.30
These data are consistent with the stimulatory hypothalamic control of GH involving NE/E which exert their effects via alpha (probably alpha 1) postsynaptic stimulatory receptors.
Regulation (control) of GH
14) Confidence 0.45 Published 1984 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 6735152 Disease Relevance 0 Pain Relevance 0.31
The same pattern was seen for the effect of GH on the incorporation of 35S-sulfate.
Regulation (effect) of GH
15) Confidence 0.45 Published 1997 Journal Calcif. Tissue Int. Section Abstract Doc Link 9192516 Disease Relevance 0.35 Pain Relevance 0.15
Results of this study indicate that mandibular condyle cartilage from OA old mice responds in vitro to the addition of GH via anabolic activities of cell proliferation, sulfated proteoglycan synthesis, and possibly enhanced mineralization.
Regulation (responds) of GH in mandibular condyle associated with osteoarthritis
16) Confidence 0.45 Published 1997 Journal Calcif. Tissue Int. Section Abstract Doc Link 9192516 Disease Relevance 0.10 Pain Relevance 0.05
Indeed, whereas the influence of tricyclic antidepressants on the GH response to apomorphine is presently unknown, several reports have suggested that tricyclics may impair the GH response to clonidine for periods longer than 3 weeks following their discontinuation.
Regulation (response) of GH associated with tricyclic antidepressant and clonidine
17) Confidence 0.45 Published 1995 Journal Neuropsychobiology Section Abstract Doc Link 7566518 Disease Relevance 0.31 Pain Relevance 0.48
OBJECTIVE: The authors' objective was to characterize the effects of fluoxetine treatment on dexamethasone-induced growth hormone (GH) responses in depressed patients.
Regulation (effects) of growth hormone associated with dexamethasone and fluoxetine
18) Confidence 0.45 Published 1995 Journal Am J Psychiatry Section Abstract Doc Link 7694914 Disease Relevance 0.07 Pain Relevance 0.30
The effect of chronic administration of growth hormone (GH) to osteoporotic patients was studied using the techniques of total body neutron activation analysis, whole body counting, calcium tracer kinetics, photon absorptiometry, quantitative microradiography, and urinary hydroxyproline.
Regulation (effect) of GH in body
19) Confidence 0.45 Published 1976 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 993324 Disease Relevance 0.15 Pain Relevance 0
The effect of chronic administration of growth hormone (GH) to osteoporotic patients was studied using the techniques of total body neutron activation analysis, whole body counting, calcium tracer kinetics, photon absorptiometry, quantitative microradiography, and urinary hydroxyproline.
Regulation (effect) of growth hormone in body
20) Confidence 0.45 Published 1976 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 993324 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox