INT153008

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.66
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) molecular_function (Elane) cellular_component (Elane)
biological_process (Elane) cytoplasm (Elane)
Anatomy Link Frequency
neutrophil 4
Elane (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 58 95.52 Very High Very High Very High
anesthesia 1 92.00 High High
ischemia 1 74.64 Quite High
cytokine 16 72.32 Quite High
Potency 2 71.04 Quite High
adenocard 4 56.28 Quite High
interstitial cystitis 4 50.00 Quite Low
chemokine 6 44.56 Quite Low
Inflammatory mediators 4 43.64 Quite Low
cINOD 16 34.16 Quite Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 3 96.68 Very High Very High Very High
INFLAMMATION 80 95.52 Very High Very High Very High
Adhesions 2 94.56 High High
Pulmonary Disease 110 91.80 High High
Interstitial Cystitis 4 85.52 High High
Coronary Artery Disease 1 75.52 Quite High
Disease 36 46.68 Quite Low
Nicotine Addiction 20 5.00 Very Low Very Low Very Low
Vomiting 18 5.00 Very Low Very Low Very Low
Emphysema 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The urinary neutrophil elastase concentration was significantly higher in IC patients with pain than in healthy subjects.
Gene_expression (concentration) of neutrophil elastase in neutrophil
1) Confidence 0.66 Published 2008 Journal Scand. J. Urol. Nephrol. Section Body Doc Link 18609268 Disease Relevance 0.09 Pain Relevance 0
A synthesized neutrophil elastase inhibitor, sivelestat sodium, may be most effective when used during cardiopulmonary bypass.
Gene_expression (synthesized) of neutrophil elastase in neutrophil
2) Confidence 0.31 Published 2008 Journal Interact Cardiovasc Thorac Surg Section Abstract Doc Link 18596053 Disease Relevance 0.25 Pain Relevance 0.13
For example, PDE4 inhibitors like roflumilast (Figure 1) suppressed a variety of functions ascribed to neutrophils including protease (neutrophil elastase, matrix metalloprotease 9) and myeloperoxidase release (Jones et al 2005); oxygen radical production (Hatzelmann and Schudt 2001); and adhesion to endothelial cells (Jones et al 2005) by inhibiting the expression of ?
Gene_expression (protease) of neutrophil elastase in neutrophil associated with adhesions
3) Confidence 0.06 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.62 Pain Relevance 0.25
By week 4 roflumilast had significantly reduced the number of neutrophils and eosinophils (38% and 50%, respectively) and furthermore, there was a concomitant reduction in both neutrophil elastase and IL-8 levels (Grootendorst et al 2005).
Gene_expression (levels) of neutrophil elastase in neutrophil
4) Confidence 0.06 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.70 Pain Relevance 0.28

General Comments

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