INT153039

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 1.01

protein modification process (G2e3) Golgi apparatus (G2e3) intracellular (G2e3) cytoplasm (G2e3)

Anatomy Link Frequency Liver 1 G2e3 (Rattus norvegicus) LOC100360318 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 6 100.00 Opioid 2 99.00 mu opioid receptor 3 83.68 agonist 2 81.68 antagonist 1 80.72 methadone 1 72.96

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

BACKGROUND: Liver metabolism of morphine leads to the formation of morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), the latter possessing strong opioid activity that however differs from that of the parent compound.

M3G Binding (formation) of morphine-6-glucuronide in Liver associated with opioid and morphine

1) Confidence 0.00 Published 2008 Journal Drug Alcohol Depend Section Abstract Doc Link 18597954 Disease Relevance 0 Pain Relevance 1.01

General Comments

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