INT15305

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 51
Total Number 56
Disease Relevance 8.28
Pain Relevance 11.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
plasma 5
dorsal 3
body 3
hippocampus 2
neurons 2
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 24 100.00 Very High Very High Very High
substance P 21 100.00 Very High Very High Very High
dorsal root ganglion 9 100.00 Very High Very High Very High
Cholecystokinin 4 99.90 Very High Very High Very High
electroacupuncture 9 99.86 Very High Very High Very High
Somatostatin 4 99.80 Very High Very High Very High
Paracetamol 87 99.78 Very High Very High Very High
qutenza 97 99.66 Very High Very High Very High
Pyramidal cell 11 99.42 Very High Very High Very High
Hippocampus 531 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 10 100.00 Very High Very High Very High
Body Weight 101 99.92 Very High Very High Very High
Disease 60 99.90 Very High Very High Very High
Neointima 78 99.68 Very High Very High Very High
Cancer 9 98.08 Very High Very High Very High
Neurodegenerative Disease 6 97.64 Very High Very High Very High
Pain 73 96.92 Very High Very High Very High
Insulin Resistance 45 96.72 Very High Very High Very High
Cardiovascular Disease 17 96.38 Very High Very High Very High
Appetite Loss 62 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, BDNF ASO hindered LTM retention only when given into dorsal CA1 1 h after but not 2 h before training, suggesting that BDNF controls the biphasic requirement of mTOR during LTM consolidation through different mechanisms: an early one involving BDNF already available at the moment of training, and a late one, happening around 3 h post-training that needs de novo synthesis of this neurotrophin.


Positive_regulation (requirement) of mTOR in dorsal
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.09 Pain Relevance 0.07
We demonstrated the existence of two time windows, one around training and the other 3 h thereafter, during which a specific inhibitor of mTOR activation infused into CA1 produced clear-cut deficits in LTM for a one-trial IA task.
Positive_regulation (activation) of mTOR
2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.04
The main findings of the present study are: (1) a biphasic activation of hippocampal mTOR signaling is associated with IA training and is required for its memory formation; (2) activation of the mTOR cascade in the dorsal hippocampus is initiated by BDNF; (3) previously synthesized BDNF is rapidly released immediately after IA training whereas around 3 h after training, new synthesis of BDNF protein is needed for LTM formation; (4) learning related BDNF/mTOR cascade activation after training induces GluR1 expression in hippocampal synaptic plasma membranes; and (5) GluR1 translation during training or 3 h later is required for IA memory consolidation.
Positive_regulation (activation) of mTOR in plasma associated with hippocampus
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.05
However, little is known about the extracellular signals triggered by training that are essential to activate mTOR for the regulation of protein synthesis during memory consolidation.
Positive_regulation (activate) of mTOR
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.19
These results show that BDNF is the extracellular signal triggering mTOR activation 3 h after training.


Positive_regulation (activation) of mTOR
5) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03
The main findings of the present study are: (1) a biphasic activation of hippocampal mTOR signaling is associated with IA training and is required for its memory formation; (2) activation of the mTOR cascade in the dorsal hippocampus is initiated by BDNF; (3) previously synthesized BDNF is rapidly released immediately after IA training whereas around 3 h after training, new synthesis of BDNF protein is needed for LTM formation; (4) learning related BDNF/mTOR cascade activation after training induces GluR1 expression in hippocampal synaptic plasma membranes; and (5) GluR1 translation during training or 3 h later is required for IA memory consolidation.
Positive_regulation (activation) of mTOR in plasma associated with hippocampus
6) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.05
Here we show that consolidation of inhibitory avoidance (IA) LTM entails mTOR activation in the dorsal hippocampus at the moment of and 3 h after training and is associated with a rapid and rapamycin-sensitive increase in AMPA receptor GluR1 subunit expression, which was also blocked by intra-hippocampal delivery of GluR1 antisense oligonucleotides (ASO).
Positive_regulation (activation) of mTOR in hippocampus associated with hippocampus
7) Confidence 0.67 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.05 Pain Relevance 0.05
We began to answer these questions by examining whether BDNF triggers the activation of mTOR induced by IA training.
Spec (whether) Positive_regulation (activation) of mTOR
8) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.11
Our findings are consistent with others showing that, in vitro, BDNF upregulates local translation of PSD95 through mTOR pathway [76] and enhances the expression of GluR1 subunit of AMPA receptors via activation of mTOR [48].
Positive_regulation (activation) of mTOR
9) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.07 Pain Relevance 0.18
Previous in vitro work on hippocampal pyramidal neuron dendrites demonstrated that activation of mTOR can relieve microRNA inhibition of translation leading to structural changes in the spine [21] or suppress potassium channel Kv1.1 expression which in turn would increase excitability [19].
Positive_regulation (activation) of mTOR in dendrites associated with pyramidal cell and potassium channel
10) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.52
We found that blockade of BDNF with function-blocking anti-BDNF antibodies delivered into dorsal CA1 15 min before training abolished the IA learning-induced increase in mTOR (Figure 5A) and p70S6K (Figure 5B) phosphorylation.
Positive_regulation (increase) of mTOR in dorsal
11) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.06
Inhibitory effects of rosiglitazone on activation of mTOR in insulin-stimulated RAoSMCs
Positive_regulation (activation) of mTOR
12) Confidence 0.54 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.08 Pain Relevance 0
As shown in Fig. 1B, the activation of mTOR upon insulin stimulus was significantly inhibited by rosiglitazone in a dose-dependent manner.
Positive_regulation (activation) of mTOR
13) Confidence 0.54 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.16 Pain Relevance 0
Inhibitory effects of rosiglitazone on mTOR activation in balloon-injured OLETF rats
Positive_regulation (activation) of mTOR
14) Confidence 0.54 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.36 Pain Relevance 0
We then performed immunohistochemistry to determine the activation of mTOR during neointima expansion in OLETF rats.
Spec (determine) Positive_regulation (activation) of mTOR associated with neointima
15) Confidence 0.54 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.39 Pain Relevance 0
Interestingly, mTOR signaling was overactivated in the spleen of portal hypertensive rats, and mTOR blockade by rapamycin profoundly ameliorated splenomegaly, causing a 44% decrease in spleen size.
Positive_regulation (overactivated) of mTOR in spleen
16) Confidence 0.50 Published 2010 Journal J. Hepatol. Section Body Doc Link 20206401 Disease Relevance 0.18 Pain Relevance 0
Treatment with leptin markedly reduced food intake, AMPK activity and increased mTOR activity in exercised rats that were pretreated with vehicle, although no increase in response to leptin-induced anorexia and modulation of AMPK/mTOR pathway were detected after i.c.v. pretreatment with anti-IL-6 antibody.
Positive_regulation (increased) of mTOR associated with appetite loss
17) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.16 Pain Relevance 0
Cota et al. [14] reported that high leucine intakes affected to decrease food intake and body weight by stimulating the hypothalamic mammalian target of rapamycin (mTOR) signaling and there are relatively specific interactions among mTOR, leptin and insulin resistance.
Positive_regulation (stimulating) of mammalian target of rapamycin in body associated with body weight and insulin resistance
18) Confidence 0.49 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2867220 Disease Relevance 0.79 Pain Relevance 0
It is known that BDNF enhances the local translation of different glutamate receptor subunits, particularly the GluR1 subunit of AMPA receptor [47]–[49] through activation of mTOR [48] and that BDNF is stored in and released from glutamatergic hippocampal neurons [50].
Positive_regulation (activation) of mTOR in neurons associated with glutamate receptor
19) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.12
These results show that BDNF is the extracellular signal triggering mTOR activation 3 h after training.


Positive_regulation (triggering) of mTOR
20) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03

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