INT153052

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg, Trpv1) plasma membrane (Prkcg, Trpv1) nucleus (Prkcg)
intracellular (Prkcg) lipid metabolic process (Trpv1) response to stress (Prkcg)
Anatomy Link Frequency
afferent neurons 2
Prkcg (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 1 84.16 Quite High
Kinase C 2 75.96 Quite High
qutenza 3 75.00 Quite High
antagonist 2 72.80 Quite High
agonist 3 65.76 Quite High
substance P 1 50.04 Quite High
imagery 1 41.68 Quite Low
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that activation of NK2 receptors in afferent neurons leads to PKC-induced phosphorylation of TRPV1, resulting in sensitization of CAPS-evoked currents and slower desensitization.
PKC Positive_regulation (induced) of Phosphorylation (phosphorylation) of TRPV1 in afferent neurons
1) Confidence 0.45 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18598261 Disease Relevance 0 Pain Relevance 0.38

General Comments

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